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Definitive Diagnosis for High-Risk Breast Lesions Without Open Surgical Excision: The Intact Percutaneous Excision Trial (IPET) |
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| Authors: | Pat W. Whitworth Jean F. Simpson William R. Poller Steven M. Schonholz John F. Turner Rogsbert F. Phillips Joel M. Johnson F. David McEachin |
| Affiliation: | (1) Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN, USA;(2) Nashville Breast Center, Nashville, TN, USA;(3) Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN, USA;(4) Breast Care Center, Allegheny General Hospital, Pittsburgh, PA, USA;(5) Department of Medicine, Drexel University College of Medicine, Philadelphia, PA, USA;(6) Breast Care Center, Mercy Medical Center, Springfield, MA, USA;(7) Thyra M. Humphreys Center for Breast Health, Evangelical Community Hospital, Lewisburg, PA, USA;(8) Metro Surgical Associates, Lithonia, GA, USA;(9) Department of Surgery, Tift Regional Medical Center, Tifton, GA, USA |
| Abstract: | BackgroundOpen surgical excision (OSE) is generally recommended when image-guided core-needle breast biopsy demonstrates a high-risk lesion (HRL). We evaluated intact percutaneous excision (IPEX) with standard radiologic and histologic criteria for definitive diagnosis of HRL, particularly atypical ductal hyperplasia (ADH). The primary aim is to confirm criteria associated with <2% risk for upgrade to carcinoma, equivalent to risk associated with Breast Imaging Reporting and Data System (BI-RADS) 3 lesions, for which imaging surveillance is considered sufficient. |
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