TREATMENT OF 23 PATIENTS WITH ADVANCED GASTRIC CANCER BY INTRAVENOUSLY TRANSFER OF AUTOLOGOUS TUMOR-INFILTRATING LYMPHOCYTES COMBINED WITH rIL-2

Tumot-infiltratiug lymphocytes (TIL) isolated from metastatic lymph nodes in patients with nonoperable advanced gastric cancer were induced to become LAK-like cytotoxic activity of TIL after in vitro culture with rlL-2.Twenty-three patients with advanced gastric cancer were tratd by intravenously transfer of autologous TIL combined with rlL-2.The tumor focus disappeared (complete remission,CR) in 3 patients (13.0%) and significantly decreased (partial remission,PR) in 5 patients (21.7%).Fifteen patients did not respond to the treatment.The amount of soluable IL-2 receptor in serum was significantly decreased after treatment,the cytotoxicity of NK cells and OT test were significantly increased.No significant difference in CD4/CD8 was found between before and after treatment.No serious side effect was obseved in the treatment.