肾综合征出血热患者血清超氧化物歧化酶、丙二醛含量和T淋巴细胞亚群的关系

目的:探讨肾综合征出血热(HFRS)发病机理中,自由基(OFR)对T淋巴细胞亚群的影响。方法:对54例HFRS患者进行血清SOD、MDA、T细胞亚群进行动态观察。结果:显示SOD含量在发热期明显低于正常对照组,MDA含量在发热期明显高于正常对照组,CD4 细胞在发热期明显降低,CD8 细胞在发热期明显升高,其变化在少尿期最重,并且发现MDA和T细胞亚群变化有一定的相关性,即MDA与CD8 细胞百分比是正相关,与CD4 /CD8 负相关。结论:HFRS患者免疫功能紊乱现象与OFR反应有关。

Study on the serum SOD,MDA and their relationship with T cell subsets in patients with hemorrhagec fever with syndrome

Objective:To study the correlation between the effects of oxygen free radicals (OFR) with T cell subsets on pathogenesis of hemorrhagic fever with syndrome(HFRS).Methods:Serum levels of SOD and MDA.T cell subsets in 54 patients with HFRS were sequentially investigate and correlation. Results:The level of serum SOD in febrile phase was lower than that of normal control.The level of serum MDA in febrile phase was higher than that of normal group;the sum of CD4 cell in febrile phase was signficantly lower than that normal group,CD8 cell was significantly higher than that of control group,and its changes must severe in oliguric phase.The resuts also showed that there was sum correlation existed between MDA and T cell subsets.Conclusion:These findings demonstrated that irregulating immunity of HFRS patients was correlation with OFR.