| 药物运输泵与难治性癫痫 |
| |
| 引用本文： | 吴春春,段德义,丁成云,徐群渊.药物运输泵与难治性癫痫[J].医学综述,2006,12(7):420-422. |
| |
| 作者姓名： | 吴春春 段德义 丁成云 徐群渊 |
| |
| 作者单位： | 1. 首都医科大学北京神经科学研究所,北京,100069
2. 首都医科大学天坛医院神经内科,北京,100050 |
| |
| 基金项目： | 中国科学院资助项目;北京市自然科学基金;北京市教委科技发展基金 |
| |
| 摘 要： | 癫痫患者耐药机制各不相同,其中运输泵机制能限制抗癫痫药物到达癫痫发作部位而引起耐药。运输泵中最典型的是P-糖蛋白(P-glycoprotein,P-gp),主要表达在一些有分泌功能的器官和血脑屏障中,能限制亲脂性药物进入脑内。抗癫痫药物在理论上似乎可以是P-gp的底物,过表达的P-gp降低了这些药物在癫痫灶内的浓度从而引起耐药。这一观点为难治性癫痫的治疗带来了新的希望,如运用一些运输泵的抑制剂来提高脑内抗癫痫药物浓度。
|
| 关 键 词： | 难治性癫痫 P-糖蛋白 药物运输泵 抗惊厥药 |
| 文章编号： | 1006-20a4（2006）07-0420-03 |
| 收稿时间： | 2005-11-09 |
| 修稿时间： | 2006-01-11 |
Drug Transporter and Refractory Epilepsy |
| |
| WU Chun-chun, DUAN De-yi , DING Cheng-yun,et al..Drug Transporter and Refractory Epilepsy[J].Medical Recapitulate,2006,12(7):420-422. |
| |
| Authors: | WU Chun-chun DUAN De-yi DING Cheng-yun |
| |
| Institution: | 1, Beijing Research Institute of Neuroscience , Capital University of Medicine, Beijing 100069, China ; 2, Department of Neurology, Tiantan Hospital of Capital University of Medicine, Beijing 100050, China |
| |
| Abstract: | Epileptics have their own mechanism of drug fast in which one is caused by drug traneportor who can restrict the anti-epileptic drug to its site of action.The most typical transporter is P-glyeopretein expressed in many organs having excrctive function and blood-brain barrier which can restrict lipotrupy drug to brain. Antiepileptic drugs seem to he the substrate of p-glycoprotein in theory. Overexpreasion of P-GP reduce the concentration of antiepileptic drugs in epileptic focus. This then caused drug fast. This view brings new hope for epilepsy treatment, such as using some inhibitors of P-gp to increace the antiepileptic drug concentration in brain. |
| |
| Keywords: | Refratory epilepsy P-glycoprotein Drag transporter Anticonvalsant |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
