| 手性拆分技术及其在手性药物合成中的应用新进展 |
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| 引用本文： | 杨千姣,刘 丹,曲 蕾,吴族悌,赵临襄. 手性拆分技术及其在手性药物合成中的应用新进展[J]. 中国药物化学杂志, 2009, 19(6) |
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| 作者姓名： | 杨千姣 刘 丹 曲 蕾 吴族悌 赵临襄 |
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| 作者单位： | （沈阳药科大学 制药工程学院 药物化学系，辽宁 沈阳110016） |
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| 摘 要： | 手性拆分是获得手性药物的重要途径，该文对经典的结晶法拆分、动力学拆分和色谱分离法拆分等手性拆分方法的新进展进行综述，并介绍膜拆分法、萃取拆分法等新技术在手性药物合成中的应用。
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| 关 键 词： | 手性药物；手性拆分；膜拆分法；萃取拆分 |
| 收稿时间： | 2009-09-07 |
| 修稿时间： | 2009-10-10 |
Application progress of novel optical resolution technologies in the chiral drugs |
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| YANG Qian-jiao,LIU Dan,QU Lei,WU Zu-ti,ZHAO Lin-xiang. Application progress of novel optical resolution technologies in the chiral drugs[J]. Chinese Journal of Medicinal Chemistry, 2009, 19(6) |
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| Authors: | YANG Qian-jiao LIU Dan QU Lei WU Zu-ti ZHAO Lin-xiang |
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| Affiliation: | (Department of Medicinal Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China) |
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| Abstract: | Up to date, optical resolution is the important approach to prepare chiral drugs. Classical optical resolution methods include crystallization resolution, kinetic resolution and chromatographic methods. New progresses of these methods are reviewed and the application of membranous resolution and extractive resolution in the preparation of chiral drugs are introduced in this paper. |
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| Keywords: | chiral drugs optical resolution membranous resolution extractive resolution |
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