| 2型糖尿病心血管病变患者联合3项检测的意义 |
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| 引用本文： | 包海林.2型糖尿病心血管病变患者联合3项检测的意义[J].检验医学与临床,2011,8(23):2852-2853. |
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| 作者姓名： | 包海林 |
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| 作者单位： | 江苏省海安县中医院检验科,226600 |
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| 摘 要： | 目的评估2型糖尿病(T2DM)心血管病变患者联合检测糖化血红蛋白A1C(HbA1C)、肌钙蛋白I(cTnI)及超敏C反应蛋白(hs-CRP)的意义。方法 137例T2DM患者作为病例组,分为糖尿病组(DM组)、糖尿病心肌病组(DCM组)及糖尿病合并冠心病组(DM合并CHD组)。其中DM合并CHD组又分为稳定型心绞痛组(SA组)、不稳定型心绞痛组(UA组)、心肌梗死组(MI组)3个亚组。30例健康体检者作为健康对照组。分别测定各组HbA1C、cTnI及hs-CRP水平,分析其相关性。结果 (1)病例组HbA1C、cTnI和hs-CRP水平明显高于健康对照组(P<0.01)。(2)HbA1C水平在病例组间比较差异无统计学意义(P>0.05),cTnI和hs-CRP水平逐渐升高(P<0.01)。SA及UA组cTnI升高不明显(P>0.05),而hs-CRP已明显升高(P<0.01)。MI组cTnI与hs-CRP升高最为明显(P<0.01)。Spearman等级相关分析提示,cTnI与hs-CRP水平与DM合并CHD各组病情呈正相关(cTnI:r=0.759,P<0.05;hs-CRP:r=0.733,P<0.05)。(3)DM合并CHD组hs-CRP水平是DM组的3倍以上,DCM组是DM组的2倍以上。结论联合检测HbA1C、cTnI、hs-CRP可以较全面地反映T2DM患者平均血糖水平、心肌受损程度以及心血管慢性炎性反应状态,可作为早期预防、诊断T2DM心血管病变有效的综合性指标。
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| 关 键 词： | 2型糖尿病 心血管病变 糖化血红蛋白A1C 肌钙蛋白I 超敏C反应蛋白 |
The significance of combining detection of three indicators in T2DM patients with cardiovascular disease |
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| BAO Hai-ling.The significance of combining detection of three indicators in T2DM patients with cardiovascular disease[J].Laboratory Medicine and Clinic,2011,8(23):2852-2853. |
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| Authors: | BAO Hai-ling |
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| Institution: | BAO Hai-ling(Department of Clinical Laboratory,Traditional Medicine Hospital of Haian County,Jiangsu 226600,China) |
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| Abstract: | Objective To evaluate the significance of combining detection of HbA1C,cTnI and hs-CRP in T2DM patients with cardiovascular disease.Methods 137 T2DM patients chosen as care group was divided into 3 subgroups:diabetic mellitus(DM),diabetic cardiomyopathy(DCM) and DM with coronary heart disease(DM with CHD).DM with CHD group was divided into 3 subgroups:stable angina(SA),unstable angina(UA),myocardial infarction(MI).30 healthy volunteers were chosen as the control group.Then we detected the level of HbA1c,cTn... |
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| Keywords: | T2DM cardiovascular disease HbA1c cTnI hs-CRP |
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