2008～2010年某院金黄色葡萄球菌感染现状及耐药性分析

目的了解金黄色葡萄球菌感染现状及耐药情况,为临床诊断疾病与合理使用抗菌药物提供科学依据。方法回顾性分析2008～2010年来临床各类送检标本中金黄色葡萄球菌的分布、耐药性状况及感染趋势。结果分离出的1 102株金黄色葡萄球菌主要来源于痰液(41.65%)、伤口分泌物(27.22%)、体液(14.16%);药敏结果显示,金黄色葡萄球菌对常用抗菌药物均有较高耐药率,但尚未发现对万古霉素耐药菌株,对糖肽类抗菌药物和新型抗菌药物利奈唑胺敏感率为100%;同时检出菌株有逐年增高趋势。结论金黄色葡萄球菌对常用抗菌药物显示多药耐药,医院应切实进行抗菌药物使用管理,延缓金黄色葡萄球菌临床耐药株的增长。

Study on antibiotic resistance and nosocomial infections status of staphylococcus aureus in a hospital from 2008 to 2010

Objective To investigate the antibiotic resistance and nosocomial infections status of Staphylococ cus aureus （SAU） and to provide scientific evidence for disease diagnosis and reasonable use of antibiotics. Methods Retrospective review was performed to analyze the specimen＇s clinical distribution,antibiotic resistance, and nosoco mial infections status of SAU from 2008 to 2010. Results 1 102 strains of SAU were mainly isolated from sputum, wounds, secretion,and body fluid. The results of susceptibility test showed that SAU had been resistant to the corn monly used antibiotics in higher degree. The drug sensitivity rate of glycopeptide antibiotics and linezolid were all 100% ,but the vancomycin- -resistance strains were not observed. Meanwhile, the detected strains increased year by year. Conclusion SAU shows multidrug resistance to the commonly used antibiotics. In order to postpone the development of drug-resistance and to prevent the prevalence of nosocomial infections, the monitoring and controlling should be strengthened.