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| 肝细胞生长因子对大鼠急性胃粘膜损伤预防作用的研究 | |
| 引用本文： | 倪金良,邓长生. 肝细胞生长因子对大鼠急性胃粘膜损伤预防作用的研究[J]. 医学新知杂志, 1999, 9(1): 9-12 |
| 作者姓名： | 倪金良 邓长生 |
| 作者单位： | 1. 扬州大学医学院附属医院消化内科,扬州,225001 2. 湖北医科大学附属第二医院消化内科,武汉,430071 |
| 摘 要： | 为了探讨内源性肝细胞生长因子（ＨＧＦ）对大鼠急性胃粘膜损伤（ＡＧＭＬ）的预防作用，以粘膜电位（ＰＤ）、ｐＨ损伤指数（ＬＩ）及组织学观察评价ＡＧＭＬ状况。结果显示，大鼠ＡＧＭＬ前静注适量肝素可以使胃粘膜中ＨＧＦ含量增加，且ＨＧＦ含量增加的大鼠胃ＰＤ、ｐＨ较对照组增高，ＬＩ降低，组织损伤改善。研究表明，大鼠ＡＧＭＬ前以肝素诱生的内源性ＨＧＦ可以预防随后的ＡＧＭＬ。 |
| 关 键 词： | 肝细胞生长因子 胃粘膜损伤 预防 |
Preventing Effect of HGF on Acute Gastric Mucosal Lesions in Rats |
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| Ni Jinliang,Deng Changsheng. Preventing Effect of HGF on Acute Gastric Mucosal Lesions in Rats[J]. Journal of New Medicine, 1999, 9(1): 9-12 | |
| Authors: | Ni Jinliang Deng Changsheng |
| Abstract: | The authors are to study afort whether endogenous hepatocyte growth factor (HGF) has a prevnting effect on acute gastric muonl lesions (AGML) in rats. Heparin and tetradecanoyl-phorhal- acetate (TPA ) are injected togther to induce entonous HGF, and then gastric mucosal pH, poential difference (PD) and lesion index (LI) are used to evaluate the mucosal lesion. The results show that HGF induced before AGML does have the preventing effect. |
| Keywords: | HGF Acute-Gastric-Mucosal-lesions Preventing effect Heparin Phorbol-Ester Rats |
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