Adenosine potentiation of neuromuscular blocking agents in guinea-pigs |
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Authors: | Nitahara K Kornak P Nagashima H Vizi E S Foldes F F Dan K |
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Institution: | Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA. |
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Abstract: | We have investigated the effects of adenosine i.v. on neuromuscular block
induced by rocuronium, vecuronium and pipecuronium in an in vivo guinea-pig
sciatic nerve-tibialis anterior preparation. The ED50 of each neuromuscular
blocker was determined from cumulative log dose- response regression lines
(n = 14). In separate experiments, adenosine 0.1 mg kg-1 min-1 or the same
volume of 0.9% NaCl was given i.v. via a constant infusion and the ED50 of
each neuromuscular blocking agent was then administered (n = 24). Adenosine
0.1 mg kg-1 min-1 increased significantly maximal block induced by the ED50
of these neuromuscular blockers (55-72%, 49-73% and 60-96%, respectively,
for rocuronium, vecuronium and pipecuronium; P < 0.05). Time to maximal
block after rocuronium was significantly prolonged by adenosine (1.4-2.1
min; P < 0.05) and time to maximal block after vecuronium and
pipecuronium was unchanged by adenosine. Time to maximal recovery of twitch
tension after administration of the ED50 of all neuromuscular blocking
agents was prolonged significantly by adenosine (4.5-10.7 min, 8.2-15.8 min
and 47.0-128.7 min, respectively, for rocuronium, vecuronium and
pipecuronium; P < 0.05). We conclude that continuous infusion of
adenosine 0.1 mg kg-1 min-1 potentiated the effects of neuromuscular
blocking agents in this in vivo guinea-pig preparation.
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