消痰散结方对人胃癌裸鼠移植瘤血管生成拟态的影响

目的 探讨消痰散结方对人胃癌裸鼠移植瘤血管生成拟态（vasculogenic mimicry，VM）的影响及其机制。 方法 30只裸鼠右前肢腋部皮下移植人胃癌瘤块建立荷瘤模型。造模后的荷瘤鼠随机分为模型组（10只）、消痰散结组（10只）和多西环素组（10只），分别给予相应药物灌胃治疗4周后，脱颈椎处死荷瘤鼠。剥取肿瘤，称取瘤质量，计算抑瘤率；计数肿瘤中VM的数量；运用免疫组织化学法检测肿瘤中基质金属蛋白酶2（matrix metalloproteinase-2，MMP-2）和基质金属蛋白酶9（matrix metalloproteinase-9，MMP-9）蛋白的表达。

Effects of Xiaotan Sanjie Recipe on Vasculogenic Mimicry of Human Gastric Cancer Xenografts in Nude Mice

Objective To study the effect of Xiaotan Sanjie Recipe(XTSJD) and its mechanism on vasculogenic mimicry(VM) of human gastric cancer xenografts in nude mice.Methods The tumor-bearing mice model was established by subcutaneous inoculating with xenografts of human gastric cancer into the right armpit of 30 BALB/c nude mice.After modeling,the tumor-bearing mice were randomly divided into the normal saline group,the XTSJD group,and the doxycycline hyclate(DH) group,10 in each.And the mice were administered with ...