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Combined cytoreductive laser therapy and immunotherapy for palliation of metastatic renal cell carcinoma to the head and neck |
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| Authors: | M. B. Paiva J. A. Sercarz A. J. Pantuck M. Polyakov R. A. Figlin R. F. Canalis D. J. Castro |
| Affiliation: | (1) Division of Head and Neck Surgery, Department of Surgery, David Geffen School of Medicine-UCLA, 10833 Le Conte Avenue, CHS62-132, P.O. Box 162418, Los Angeles, CA 90095-1624, USA;(2) Division of Urology, Department of Surgery, David Geffen School of Medicine-UCLA, 10833 Le Conte Avenue, CHS62-132, Los Angeles, CA 90095-1624, USA;(3) Department of Medicine, David Geffen School of Medicine-UCLA, 10833 Le Conte Avenue, CHS62-132, Los Angeles, CA 90095-1624, USA |
| Abstract: | Interleukin-2 (IL-2) remains the mainstay of treatment for metastatic renal cell carcinoma (RCC), but minimally invasive surgical techniques have provided new options for the combined treatment of RCC. Two patients with metastatic RCC to the head and neck treated by combined laser-induced thermal therapy and IL-2 were described in this case report. Both patients had an extended survival compared to the historical survival of 10 months for metastatic RCC but eventually succumbed to progressive disease. The authors’ initial experience with metastatic RCC suggests that laser thermoablation and immunotherapy in selected patients with metastatic RCC is warranted as a palliative treatment, but a larger study with long-term follow-up is necessary to determine the effectiveness of this approach. |
| Keywords: | Laser-induced thermotherapy Renal cell carcinoma Metastatic head and neck cancer Immunotherapy IL-2 Nd:YAG laser |
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