| HPLC法测定右旋布洛芬缓释胶囊有关物质 |
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| 引用本文： | 邹尚荣,申坤,李燕青. HPLC法测定右旋布洛芬缓释胶囊有关物质[J]. 海峡药学, 2014, 26(2): 59-63 |
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| 作者姓名： | 邹尚荣 申坤 李燕青 |
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| 作者单位： | 邹尚荣 (广东省广州市第八人民医院药剂科,广州,510060)； 申坤 (广东省广州市第八人民医院药剂科,广州,510060)； 李燕青 (广东省广州市第八人民医院药剂科,广州,510060)； |
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| 摘 要： | 目的 建立HPLC法测定右旋布洛芬缓释胶囊中的有关物质.方法 色谱柱为ODS-C18色谱柱（250mm×4.6mm,5μm,流动相为乙腈-磷酸二氢钾溶液（调pH 3.5）（体积比60：40）,右旋布洛芬检测波长264nm,左旋体检测波长为351nm.结果本法能有效地分离右旋布洛芬缓释胶囊中的左旋体及有关物质.结论 方法简便,专属性好,结果准确,可用于右旋布洛芬缓释胶囊的质量控制.
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| 关 键 词： | 右旋布洛芬缓释胶囊 有关物质 质量控制 |
Determination of related substances in sustained-release capsules of Dexibuprofen by HPLC |
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| ZOU Shang-rong,SHEN Kun,LI Yan-qing. Determination of related substances in sustained-release capsules of Dexibuprofen by HPLC[J]. Strait Pharmaceutical Journal, 2014, 26(2): 59-63 |
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| Authors: | ZOU Shang-rong SHEN Kun LI Yan-qing |
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| Affiliation: | ( Pharmacy Department, Guangzhou Eighth People＇s Hospital, Guangzhou 510060, China) |
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| Abstract: | OBJECTIVE To establish a HPLC method for determination of related substances in sustained-release capsules of Dexibuprofen. METHODS The substances were analyzed on an Hypersil ODS-C18 HPLC column （250mm × 4.6mm,5μm） with the mobile phase consisted of acetonitrile potassium dihydrogen phosphate （pH 3.5） （60：40 v/v）. The detection wavelength was 264nm for Dexibuprofen, while 351nm for the L-Ibupro- fen. RESULTS This method can availably separate the L-Ibuprofen and other related substances in sustained-re- lease capsules of Dexibuprofen. CONCLUSION This method is simple, high specificity and accurate. It can be used for quality control of sustained-release capsules of DexibuDrofen. |
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| Keywords: | HPLC Sustained-release capsules of Dexibuprofen Related substances Quality control |
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