| 调经活血胶囊质量标准研究 |
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| 引用本文： | 彭飞城,丁野,郑金凤,李文莉.调经活血胶囊质量标准研究[J].海峡药学,2014,26(1):53-55. |
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| 作者姓名： | 彭飞城 丁野 郑金凤 李文莉 |
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| 作者单位： | 彭飞城(湖南省食品药品检验研究院,长沙,410001)；丁野(湖南省食品药品检验研究院,长沙,410001)；郑金凤(湖南省食品药品检验研究院,长沙,410001)；李文莉(湖南省食品药品检验研究院,长沙,410001)； |
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| 基金项目： | 国家药典委员会编国家药品质量标准提高行动计划项目(项目编号：618) |
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| 摘 要： | 目的 提高完善调经活血胶囊质量标准.方法 采用薄层色谱法对丹参、熟地黄进行鉴别;采用高效液相色谱法测定赤芍中芍药苷含量,色谱柱为Agilent Zorbax-SB C18（250mm×4.6mm,5μm）,流动相为甲醇-水（25：75）,柱温：35℃,流速：0.8mL·min-1,检测波长：230nm.结果 薄层色谱斑点清晰,分离效果良好;芍药苷对照品在0.01201～2.156μg范围内线性关系良好（r=0.9996）,平均回收率为96.61%,RSD为1.21% （n=9）.结论 本法简便、可靠、准确,可用于该制剂的质量控制.
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| 关 键 词： | 调经活血胶囊 质量标准 薄层色谱法 高效液相色谱法 |
Studies on quality standard for Tiaojing Huoxue Capsules |
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| PENG Fei-cheng,DING Ye,ZHENG Jin-feng,LI Wen-li.Studies on quality standard for Tiaojing Huoxue Capsules[J].Strait Pharmaceutical Journal,2014,26(1):53-55. |
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| Authors: | PENG Fei-cheng DING Ye ZHENG Jin-feng LI Wen-li |
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| Institution: | (Hunan Institute for Food and Drug ControI,Chan- gsha 410001, China) |
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| Abstract: | OBJECTIVE To improve quality standard of Tiaojing Huoxue Capsules. METHODS Salviae Milt- iorrhizae Radix et Rhizoma and Rehmanniae Radix Praeparata were identified by TLC;The content of peoniflorin in Paeoniae Radix Rubra was determined by HPLC. An Agilent Zorbax-SB Cls （4. 6 mm × 250 mm,5μm） column was eluted with mobile phase consisted of methanol-water（25：75 ） at the column temperature of 35℃. The flow rate was 0. 8mL · min-1 and detective wavelength was 230nm. RESULTS The spots in TLC were quite clear. The linear range of peoniflorin was within 0. 01201 ~ 2. 156μg（ r = 0. 9996）, the average recovery of peoniflorin was 96. 61% with RSD of 1.21% （ n = 9）. CONCLUSION The established method is simple, reliable, accurate and can be used as the quality control of Tiaojing Huoxue Capsules. |
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| Keywords: | Tiaojing Huoxue Capsules Quality Standard TLC HPLC |
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