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不同时期慢性阻塞性肺疾病患者血清炎性因子水平和肺功能情况分析
引用本文:陈永春,王天轶. 不同时期慢性阻塞性肺疾病患者血清炎性因子水平和肺功能情况分析[J]. 华北国防医药, 2017, 29(4). DOI: 10.3969/j.issn.2095-140X.2017.04.010
作者姓名:陈永春  王天轶
作者单位:解放军白求恩国际和平医院呼吸科,石家庄,050082
基金项目:河北省科技计划项目课题
摘    要:目的 探讨不同时期慢性阻塞性肺疾病(COPD)患者血清炎性因子水平和肺功能情况.方法 选择2013年2月-2015年2月收治的COPD 200例,分为急性加重期组和稳定期组,每组100例.选择同期健康体检者100例作为对照组.检测3组血清炎性因子水平和肺功能,并探讨二者的相关性.结果 急性加重期组和稳定期组白介素-1β (IL-1β)、IL-6、IL-8、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)和结缔组织生长因子(CTGF)均高于对照组,IL-2低于对照组(P<0.05);急性加重期组IL-2低于稳定期组,其余指标均高于稳定期组(P<0.05).稳定期组和急性加重期组肺功能各指标均低于对照组,且急性加重期组低于稳定期组(P<0.05).结论 IL-1β、IL-8、IL-2、TNF-α、IL-6、CTGF和IFN-γ是评估COPD病情的重要指标,对临床治疗具有一定的指导作用.

关 键 词:肺疾病,慢性阻塞性  炎性因子  肺功能

Analysis of Serum Inflammatory Factor and Lung Function Conditions in Patients with COPD in Different Periods
CHEN Yong-chun,WANG Tian-yi. Analysis of Serum Inflammatory Factor and Lung Function Conditions in Patients with COPD in Different Periods[J]. Medical Journal of Beijing Military Region, 2017, 29(4). DOI: 10.3969/j.issn.2095-140X.2017.04.010
Authors:CHEN Yong-chun  WANG Tian-yi
Abstract:Objeetive To investigate conditions of inflammatory factor and lung function in patients with chronic obstructive lung disease (COPD) in different periods.Methods A total of 200 COPD patients between February 2013 and February 2015 were divided into acute exacerbation and stable period groups (n =100 for each group),and other 100 normal persons taking medical examination were selected as control group.Serum inflammatory factor and lung function levels were detected,and correlation between the two levels were analyzed in three groups.Results Interleukin-1 β (IL-1 3),IL-6,IL-8,tumor necrosis factor-c (TNF-α),interferon-γ (IFN-γ) and connective tissue growth factor (CTGF) levels were significantly higher in acute exacerbation and stable period groups,while IL-2 levels were significantly lower than those in control group (P < 0.05).In acute exacerbation group,IL-2 level was significantly lower,while the other indicators were significantly higher than those in stable period group (P < 0.05).Levels of lung function in acute exacerbation and stable period groups were significantly lower than those in control group,and the levels in acute exacerbation were significantly lower than those in stable period group (P < 0.05).Conclusion IL-1β,IL-8,IL-2,TNF-α,IL-6,CTGF and IFN-γ are important indexes in evaluation of COPD condition.
Keywords:Pulmonary disease,chronic obstructive  Inflammatory factor  Lung function
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