RAD51在散发性结肠腺瘤癌变过程中的表达和意义

目的研究散发性结肠腺瘤癌变中RAD51的表达和意义。方法采用免疫组织化学法检测71例结肠黏膜、66例散发性结肠腺瘤伴上皮内瘤变和98例结肠腺瘤癌变中RAD51蛋白表达情况,并分析RAD51与结肠癌临床病理特征的关系。结果①在结肠黏膜组、腺瘤组和癌变组中,RAD51的表达水平逐渐升高（P〈0.05）。②在腺瘤癌变组中,RAD51的表达与肿瘤的分化程度、淋巴结转移有关（P〈0.05）。③在腺瘤组中,伴高级别上皮内瘤变RAD51的阳性表达高于低级别上皮内瘤变（P〈0.05）。结论在结肠腺瘤癌变的发生发展过程中,RAD51起重要作用。

THE EXPRESSION AND SIGNIFICANCE OF RAD51 IN CARCINOGENESIS OF SPORADIC COLORECTAL ADENOMA

Objective To investigate the expression and significance of RAD51in carcinogenesis of sporadic colorectal adenoma.Methods The expression of RAD51 was studied by immunohistochemistry in 71 cases of colorectal mucosa,66 cases of sporadic colorectal adenoma with dysplasia and98 cases of canceration of colorectal adenoma.The relationship between RAD51 and clinical pathological features of colorectal cancer was analyed.Results In the colorectal mucosa,adenoma and carcinoma group, the expression of RAD51 increased gradually（P〈0.05）.In the adenoma carcinoma group,the expression of RAD51 was associated with tumor differentiation and lymph node metastasis（P〈0.05）. The positive expression of RAD51 was significantly higher in adenoma with high grade intraepithelial neoplasia than those with low grade intraepithelial neoplasia（P〈0.05）.Conclusion RAD51 plays an important role in the process of colonic adenomas canceration.