鲑鱼降钙素联合钙尔奇D治疗糖尿病伴骨质疏松的疗效观察

目的探讨鲑鱼降钙素联合钙尔奇D治疗糖尿病伴骨质疏松症患者的疗效及安全性。方法 16例糖尿病伴骨质疏松症患者用鲑鱼降钙素50IU1次/d,肌肉注射,同时服用钙尔奇D,600mg/d,连续治疗4个周。在治疗前、治疗后分别测量骨密度（BMD）、骨代谢指标骨钙素（BGP）,血钙、血磷、肝肾功能等,观察骨质疏松症腰背疼痛症状的治疗效果。结果治疗4个周后骨密度较治疗前明显升高,骨钙素显著高于治疗前,甲状旁腺激素和碱性磷酸酶二者显著减低,腰背疼痛等骨病症状减轻甚至消失。结论鲑鱼降钙素加钙尔奇D能够抑制骨吸收,促进骨形成,降低骨转换,并能迅速改善腰背疼痛症状,对糖尿病伴骨质疏松症治疗效果显著。

The Efficacy of Salmon Calcitonin combined with Caltrate D in Treatment of Diabetes Mellitus complicated with Osteoporosis

Objective To study the efficacy and safety of salmon calcitonin combined with caltrate D in treatment of diabetes mellitus complicated with osteoporosis.Methods 16 patients with diabetes mellitus complicated with osteoporosis were given salmon calcitonin,50IU,im,qd,and caltrate D 600 mg/d for 4 weeks.The bone mineral density（BMD）,bone metabolic markers osteocalcin（BGP）,serum calcium,phosphorus,liver and kidney function were measured before and after treatment to observe the treatment effect of osteoporosis with pain on low back.Results After 4 weeks of treatment the BMD and BGP were significantly higher,parathyroid hormone and alkaline phosphatase were significantly lower,the symptoms of bone disease like the low back pain reduced or disappeared.Conclusion Salmon calcitonin combined with caltrate D can inhibit bone resorption and promote bone formation,reduce bone change,and rapidly improve the symptoms of low back pain,and has significant effect in treatment of diabetes mellitus complicated with osteoporosis.