新生儿多器官损害相关危险因素分析

目的:探讨新生儿多器官损害(MOD)与出生时体质量(BW)、胎龄(GA)及1 min、5 min Apgar评分相关性.方法:对269例伴有MOD新生儿按BW<1500 g、1500～<2500 g、2500～4000 g分为3组,按GA<32周、32～<37周、37～42周分为3组,按Apgar评分1 min≤7分及8～10分、5 min≤7分及8～10分各分为2组,分别统计各组MOD发生率;比较不同BW及GA各组器官损害个数(2个、3个、3个以上).结果:随着BW和GA的增加,MOD发生率降低(P<0.01);3组3个及3个以上脏器损害发生率随BW下降、GA减小而增加(P<0.01).1 min、5 min Apgar评分≤7分组MOD发生率均>8～10分组(P<0.01).结论:低BW、早产儿、低Apgar评分尤其是5 min Apgar评分是新生儿MOD的危险因素,MOD发生率、脏器损害个数均与BW及GA呈负相关.

Analysis of the related risk factors of neonatal multiple organ damage

Objective:To investigate the correlations between neonatal multiple organ damage ( MOD ) , and birth weight ( BW ) , gestational age( GA) ,1-and 5-minute Apgar scores. Methods:Two hundred and sixty-nine newborns with MOD were divided into the<1500 g,1500 g to <2500 g,and 2500 to 4000 g groups according to BW,<32 weeks,32 to <37 weeks,and 37 to 42 weeks groups according to GA,and ≤7 and 8 to 10 scores of 1-minute and 5-minute groups according to the Apgar score. The incidence of MOD in each group was calculated. The incidence rates of the number of organ damage(2,3,or more than 3) in different BW and GA groups were compared. Results:With the increasing of BW and GA,the incidence rate of MOD decreased(P <0. 01). With the decreasing of BW and GA,the incidence rate of number of organ damage(3,or more than 3) increased(P<0. 01). The incidence rate of MOD in 1-minute and 5-minute Apgar scores≤7 patients was more than that in 1-minute and 5-minute Apgar scores for 8 to 10 patients(P<0. 01). Conclusions:Low BW,premature babies and low Apgar score,especially the low 5-minute Apgar score,are the risk fators of neonatal MOD. The incidence rate of MOD and number of organ damage are negatively correlated with BW and GA.