亚临床甲状腺疾病与稽留流产的相关性研究

目的:分析亚临床甲状腺疾病与稽留流产相关性,降低稽留流产率.方法:收集稽留流产病人71例为观察组,正常妊娠孕妇80名为对照组,检测其血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺球蛋白抗体(TGAb)及甲状腺微粒体抗体(TMAb)水平并分组进行比较,随访妊娠结局.结果:观察组FT3、FT4、TSH、TGAb、TMAb水平与对照组差异均无统计学意义(P>0.05).观察组亚临床甲状腺疾病患病率高于对照组(P<0.01),主要为亚临床甲状腺功能减退(TSH增高型),甲状腺自身抗体及亚临床甲状腺功能亢进患病情况无明显差异(P>0.05).结论:亚临床甲状腺功能减退(TSH增高型)与稽留流产率有一定关系,亚临床甲状腺功能亢进及甲状腺自身抗体与稽留流产均无明显关系;亚临床甲状腺疾病对稽留流产的影响多作用于早孕期.

Research on the correlation between subclinical thyroid disease and missed abortion

Objective:To analyze the correlation between subclinical thyroid disease and missed abortion for reducing the missed abortion rate. Methods:Seventy-one patients with missed abortion and 80 normal pregnant women were divided into the observation group and control group,respectively. The serum levels of free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone (TSH),thyroglobulin antibody(TGAb) and thyroid microsomal antibody(TMAb) between two groups were compared. The pregnant outcome in two groups was followed up. Results:There was no statistical difference in the serum levels of FT3,FT4,TSH,TGAb and TMAb between two groups(P>0. 05). The incidence rate of subclinical thyroid disease in observation group was higher than that in control group(P < 0. 01),the subclinical hypothyroidism(TSH elevated type) was the main type. The differences of thyroid autoantibody and incidence of hyperthyroidism between two groups were not statistically significant(P >0. 05). Conclusions:The subclinical hypothyroidism( TSH elevated type) is correlated with the missed abortion rate,the subclinical hyperthyroidism and thyroid autoantibody are not significantly related to the missed abortion. The impact of subclinical thyroid disease on the missed abortion mainly happens on early pregnancy.