池州市艾滋病患者机会性感染与CD4+T细胞计数间的关系

目的探讨池州市HIV／AIDS（acquired immunede ficiency syndrome,AIDS）患者机会感染特点及其与CD4＋T细胞计数间的关系。方法回顾性分析池州市2005年1月—2012年2月65例HIVAIDS患者临床资料,总结患者机会感染特点、不同CD4’T细胞计数水平发生机会感染的差异;分析机会感染特点与CD4＋T细胞计数间的关系,统计学采用PearsonChi-Square检验。结果65例患者中发生机会性感染36例,感染率55．38％（36／65）。CIM＋T细胞≥200个／L的4例（19．05％）（4／21）;100〈CIM＋T细胞〈200个／L的7例（53．85％）（7／13）;50／L〈CD4＋T细胞≤100个／L的14例（53．85％）（14／20）;CD4＋r细胞≤50个／L,11例（100．00％）（11／11）。CD4＋T细胞〉100个／L,感染部位多数为2个或2个以下;而CIM＋T细胞≤100个时,多发生2个以上部位感染。常见机会感染有肺孢子菌肺炎（Pneumocystis pneumonia,PCP）、肺结核、结核性胸膜炎、肠结核、巨细胞病毒视网膜炎、淋巴瘤、消化道真菌感染、隐球菌性脑膜炎、带状疱疹和败血症。结论池州市HIV／AIDS患者机会感染发病率高,多部位感染、混合感染常见;随着CD4＋T细胞数量减少,机会感染的发病率、累及部位增加

Research between the CD4~+ T cell numeration and opportunistic infections in acquired deficiency syndrome patients in Chizhou

Objective To investigate the correlation between CD4+T cell numeration and opportunistic infections in patients with HIV/AIDS in Chizhou.Methods Retrospectively review was made of clinical features in 65 cases with HIV/AIDS,dating from January 2005 to February 2012.The difference was analyzed between CD4+T cell numeration and the incidence of opportunistic infections,the number of the locations of infection.Statistical analysis was done using Pearson Chi-Square test.Results Thirty-six cases of opportunistic infections occurred,among which there were 4 cases(19.05%)(4/21)whose CD4+T cell numeration was more than 200/L;7 cases(53.85%)(7/13),CD4+T cell numeration between 100 and 200;14 cases(53.85%)(14/20) with cell numeration 50~100,11 cases(100.00%)(100%) lower than 50.Patients had 2 or less positions infected when their CD4+T cell numeration was higher than 100/L.However,patients with CD4+T cell numeration lower than 100/L usually had more than 2 infected positions.Common opportunistic infections were pneumocystis pneumonia,pulmonary tuberculosis,tuberculous pleurisy,intestinal tuberculosis,cytomegalovirus retinitis,lymphoma,gastrointestinal fungal infection,cryptococcal meningitis,herpes zoster and septicemia.Conclusion Opportunistic infections in patients with HIV/AIDS are high in Chizhou.Multipositions and polyinfection are common in these patients.With the CD4+T cell numeration reducing,morbidity of opportunistic infections and positons are increasing.