1377例泌尿生殖道支原体感染的研究及药敏分析

目的:了解本地区泌尿生殖道支原体感染的现状及药敏情况,指导临床合理用药。方法:对1377例泌尿系感染患者进行支原体培养,采用支原体培养、药敏一体化试剂盒对其中的阳性标本进行8种抗生素药敏试验。结果:1377例患者中支原体阳性569例,感染率为41.32%;单一Uu(解脲支原体)感染、单一Mh(人型支原体)感染及Uu+Mh混合感染的感染率分别为26.32%、3.27%、11.73%;单一Uu感染显著高于单一Mh感染和Uu+Mh混合感染;药敏结果显示,敏感率最高的为强力霉素和交沙霉素,耐药率较高的包括环丙沙星、司帕沙星、罗红霉素、红霉素等。结论:本地区泌尿生殖道支原体感染应首选强力霉素和交沙霉素治疗,尤其是在无条件做药敏试验时,而对环丙沙星、司帕沙星等耐药性较高的药物,未做药敏试验时应慎重考虑。

Study on Urogenital Mycoplasma Infection of 1377 Patients and Analysis of Their Antimicrobiotial Susceptibility Test

Objective To provide a reference for clinical diagnosis and therapy through investigate Urogenital Mycoplasma infection and drug sensitivity.Methods Mycoplasma were isolated from 1377 patients with genitourinary tract infection symptoms and signs,and their antibiotic susceptibility was tested with 8 different antibiotics.Results Among all the cases,569 patients were infected with Mycoplasma(41.32 %).The simple infection of Ureaplasma urealyticum(Uu) was 362 cases(26.32 %) and Mycoplasma hominis(Mh) was 45 cases(3.27 %) respectively.The mixed infection of Uu/ Mh was 162 cases(11.73%).Uu was the major cause of Mycoplasma infection in genitourinary system.The result of drug sensitive test showed that drug sensitivity was in various extents.Doxycycline and Josamycin were more effective than other antimicrobial agents,while the susceptibilities of Ciprofloxacin,Sparfloxacin,Erythromycin,Roxithromycin were low.Conclusion It is important for us to choose antimicrobial agents according to the results of culture and antimicrobial susceptibility test for Mycoplasma infection of genitourinary tract.If antibiotic susceptibility testing can not be tested,Doxycycline and Josamycin may be locally selected as the first drugs to treat mycoplasma infection.