心肌梗死的microRNAs组学及中医药干预的研究概况

心肌梗死是人类主要死亡原因之一,易并发心律失常、心肌重构、心力衰竭等,其发病率和致死率逐年升高。microRNAs组学属于基因组学分支,是目前生命科学领域研究的热点。研究发现其在心肌梗死的病理生理过程中发挥重要作用,并调控心梗后血管生成、心律失常、心肌重构等多个过程,为心肌梗死的研究提供了新的思路和方法。中医药通过调控miRNAs表达干预心肌梗死已取得一定进展,如促进心梗后血管生成、抑制心梗后心律失常、延缓心梗后心室重构等。

Research Summary about Micrornomics and Traditional Chinese Medicine Intervention of Myocardial Infarction

Myocardial infarction, one of the main causes of death, is easy to be complicated by arrhythmia, myocardial remod- eling and heart failure, etc. And its morbidity and mortality rate are increasing year by year. MicroRNomics, belonging to genom- ics, is a research hotspot in life science field at present. Studies found that mieroRNomics played an important role in pathological and physiological process of myocardial infarction, and regulated the angiogenesis, arrhythmia, myocardial remodeling process after myocardial infarction, offering a new idea and method for the study of myocardial infarction. Traditional Chinese Medicine inter- vention in myocardial infarction through regulating miRNAs expression has made some progress, such as promoting angiogenesis, inhibiting arrhythmia, and delaying myocardial remodeling after myocardial infarction, etc.