| 急性早幼粒细胞白血病的治疗 |
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| 引用本文： | 游建华,付亚凯,沈杨. 急性早幼粒细胞白血病的治疗[J]. 临床荟萃, 2014, 29(10): 1104-1107 |
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| 作者姓名： | 游建华 付亚凯 沈杨 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院血液科,上海,200025 |
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| 摘 要： | 急性早幼粒细胞白血病(APL)是急性髓细胞白血病的一种特殊亚型.全反式维甲酸(ATRA)的应用使其从一种高度凶险的疾病转变成为一种高度可治愈的疾病.三氧化二砷(ATO)在治疗复发难治性APL取得成功后,也逐渐被引入APL的一线诱导治疗.危险度分层治疗的提出、口服砷剂的使用进一步提高了APL的疗效.本文就APL的治疗现状及其最新进展进行简要综述.
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| 关 键 词： | 白血病 |
Treatment of acute promyelocytic leukemia |
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| YOU Jian-hua,FU Ya-kai,SHEN Yang. Treatment of acute promyelocytic leukemia[J]. Clinical Focus, 2014, 29(10): 1104-1107 |
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| Authors: | YOU Jian-hua FU Ya-kai SHEN Yang |
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| Affiliation: | (Department of Hematology ,the Affiliated Ruijin Hospital of Shanghai Jiaotong University Medical College ,Shanghai 200025 ,China) |
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| Abstract: | Acute promyelocytic leukemia（APL） is a unique subtype of acute myelocytic leukemia.With the introduction of all-trans retinoic acid（ATRA）,it has been turned into a highly curable disease from a highly fatal one.Arsenic trioxide（ATO） was firstly tried in the treatment of relapsed and refractory APL and achieved a high CR rate.Then,it was applied in the first-line therapy of APL.The proposal of risk-adapted treatment and the use of oral arsenic have further improved the therapeutic efficacy.In this review,we discuss the present status and the novel approaches of the treatments for APL. |
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| Keywords: | acute promyelocytic leukemia arsenicals all-trans retinoic acid |
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