单磷酸阿糖腺苷在轮状病毒肠炎治疗中的临床疗效

目的观察单磷酸阿糖腺苷在治疗婴幼儿轮状病毒性肠炎中的临床疗效与安全性，以选择更佳的抗病毒药物。方法将确诊为轮状病毒肠炎的140例患儿按照随机的原则分为两组，每组各70例，对照组给予蒙脱石散剂（思密达），观察组给予蒙脱石散剂＋单磷酸阿糖腺苷。结果观察组总有效率（95．71％）高于对照组（85．71％），差异有统计学意义（P〈0．05）；Ridit检验结果显示，观察组R1=0．4491〈对照组R2=0．5509，表明观察组疗效优于对照组（P〈0．05）。结论在常规药物蒙脱石散剂治疗婴幼儿轮状病毒肠炎的基础上加用单磷酸阿糖腺苷，疗效确切，起效快，不良反应不明显，值得推广应用。

The clinical efficacy of Ara-adenosine in the treatment of rotavirus enteritis

Objective To observe the clinical efficacy of Ara-adenosine in the treatment of infantile rotavirus enteritis.Methods 140 patients diagnosed with rotavirus enteritis were randomly divided into the control group,which was given Smecta and the observation group,which was given Smecta + Ara-adenosine.Results The efficacy of the observation group was 95.71% and the control group was 85.71%,the difference was statistically significant(P < 0.05);The Ridit examination showed that,R1 of the observation group was 0.449 1 and R2 of the control group was 0.550 9,indicating that the efficiency of the observation group was better than that of the control group(P < 0.05).Conclusion Based on the conventional drugs smecta to treat rotavirus enteritis of infants,Ara-AMP is efficacy and rapid.What’s more,the adverse reactions are not obvious.