癌胚抗原和C-反应蛋白在结核性和恶性胸腔积液诊断中的临床意义

目的探讨癌胚抗原（CEA）和C反应蛋白（CRP）在结核性和恶性胸腔积液诊断中的临床意义。方法 120例胸腔积液患者按照病因不同分为结核性胸腔积液86例和恶性胸腔积液34例,观察两组患者胸腔积液中CEA和CRP水平。结果 CEA水平及阳性率恶性胸腔积液组明显高于结核性胸腔积液组,而CRP水平及阳性率结核性胸腔积液组明显高于恶性胸腔积液组,差异有高度统计学意义（P〈0.01）,并且CEA〉8μg/L诊断恶性胸腔积液的灵敏度为55.88%,特异性为100.0%,而CRP〉6 mg/L诊断结核性胸腔积液的灵敏度为78.18%,特异性为87.18%。结论 CRP和CEA联合监测对结核性和恶性胸腔积液鉴别诊断有较好的临床意义。

Diagostic values of carcinoembryonic antigen and C-reactive protein in differentiate between tuberculosis and malignant pleural effusion

Objective To discuss the value of carcinoembryonic antigen(CEA) and C reactive protein(CRP) in differential diagnosis of malignant pleural effusion.Methods The levels of CEA and CRP in 34 cases of neoplastic pleural effusion and 86 cases of tuberculous pleural effusion were detected and compared.Results CEA level and positive rate in pleural effusion group was significantly higher than that of malignant pleural effusion group,while the CRP level and positive rate in pleural effusion group was higher than that of tuberculosis of malignant pleural effusion group,differences were statistically significant(P < 0.01),and CEA > 8 μg/L in the diagnosis of malignant pleural effusion sensitivity was 55.88%,specificity was 100.00%,while the CRP > 6 mg/L for diagnosis of tuberculous pleural effusion sensitivity was 78.18%,specificity was 87.18%.Conclusion CRP and CEA have important value in differential diagnosis of neoplastic pleural effusion and tuberculous pleural effusion.