Effect of intraoperative intravenous crystalloid infusion on postoperative nausea and vomiting after gynaecological laparoscopy: comparison of 30 and 10 ml kg(-1) |
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Authors: | Magner J J McCaul C Carton E Gardiner J Buggy D |
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Institution: | 1 Department of Anaesthesia, Rotunda Hospital, Parnell Square, Dublin 1, Ireland. 2 Divisions of Anaesthesia, Intensive Care Medicine and The Lung Biology Programme, The Hospital For Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada. 3 Department of Anaesthesia and Intensive Care Medicine, Mater Misericordiae Hospital, Eccles St, Dublin 7, Ireland |
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Abstract: | Background. I.V. fluid administration has been shown to reducepostoperative nausea and vomiting (PONV). The optimum dose isunknown. We tested the hypothesis that administration of i.v.crystalloid of 30 ml kg1 would reduce the incidence ofPONV compared with 10 ml kg1 of the same fluid. Methods. A total of 141 ASA I female patients undergoing electivegynaecological laparoscopy were randomized, in double-blindfashion, to receive either 10 ml kg1 (n=71; CSL-10 group)or 30 ml kg1 (n=70; CSL-30 group) of i.v. compound sodiumlactate (CSL). Results. In the first 48 h after anaesthesia, the incidenceof vomiting was lower in the CSL-30 group than in the CSL-10group (8.6% vs 25.7%, P=0.01). Anti-emetic use was less in theCSL-30 group at 0.5 h (2.9% vs 14.3%, P=0.04). The incidenceof severe nausea was significantly reduced in the treatmentgroup at awakening (2.9% vs 15.7%, P=0.02), 2 h (0.0% vs 8.6%,P=0.04) and cumulatively (5.7% vs 27.1%, P=0.001). The numbersneeded to treat to prevent vomiting, severe nausea and antiemeticuse in the first 48 h were 6, 5 and 6, respectively. Conclusion. I.V. administration of CSL 30 ml kg1 to healthywomen undergoing day-case gynaecological laparoscopy reducedthe incidence of vomiting, nausea and anti-emetic use when comparedwith CSL 10 ml kg1. |
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Keywords: | anaesthesia day case anaesthetic techniques i v infusion complications nausea and vomiting fluids i v postoperative nausea and vomiting surgery laparoscopy vomiting nausea vomiting nausea anaesthetic factors vomiting nausea incidence |
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