新调心方治疗轻度认知功能损害64例临床观察

目的：研究中药新调心方对轻度认知功能损害（MCI）患者认知功能和日常生活能力的疗效。方法：收集2014年3月－12月MCI患者64例，随机分为西药（双益平）组32例和中药（新调心方）组32例，两组均治疗24周。采用简易精神状态量表（MMSE）、蒙特利尔认知评估量表（MoCA）、ADAS-cog和总体衰退评价量表评估两组患者的治疗效果。结果：与治疗前相比，治疗后两组MMSE和MoCA分值均得到改善，疗效相当，但中药组ADAS-cog改善效果较西药组更明显（P＜0.05）。与治疗前相比，治疗后两组总体衰退均有显著改善（P均＜0.01）。结论：新调心方具有补心气、温心阳、化痰开窍的功效，是治疗MCI的有效治则之一。

Clinical observation of xintiaoxinrecipe in the treatment of 64 cases of mild cognitive impairment

Objective: To study the therapeutic effect of xintiaoxinrecipe in the improving the cognitive function and ability of daily life of the patients with mild cognitive impairment(MCI).Methods:From February to December, 2014, 64 patients with MCI were collected and randomly divided into a Western medicine (huperzine) group with 32 cases and a Chinese medicine (xintiaoxinrecipe) group with 32 cases. Both groups were treated for 24 weeks. The treatment effects of the patients in the two groups were evaluated with the mini-mental state examination(MMSE), Montreal cognitive assessment(MOCA), ADAS-cog and overall evaluation scale of recession.Results: Compared with those before treatment, the scores of MMSE and MOCA were all improved after treatment and the effect was equivalent to each other. But the improvement of ADAS-cog of Chinese medicine group was better than that of the Western medicine group(P<0.05). The overall recessions of the two groups were signiifcantly improved(P<0.01).Conclusion: Xintiaoxinrecipe has the effects of buxinqi, wenxinyang, and eliminating phlegm for resuscitation and is one of the effective treatments of MCI.