Use of recombinant factor VIIa in infants with severe coagulopathy. |
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| Authors: | Magali J Fontaine John Lazarchick Sarah Taylor David Annibale |
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| Affiliation: | Department of Pathology, Transfusion Medicine Division, Medical University of South Carolina, Stanford University, Stanford, CA 94305-5626, USA. magalif@stanford.edu |
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| Abstract: | The risk of hemorrhage in infants with severe coagulopathies unresponsive to fresh frozen plasma (FFP) infusions may preclude therapeutic invasive interventional procedures. We describe the successful use of recombinant factor VIIa (rFVIIa) in two such infants, the first with cirrhosis requiring paracentesis and the second with necrotizing enterocolitis requiring laparotomy. This report reviews the current concepts on the mechanism of action of the drug rFVIIa and considers its expanded use in infants unresponsive to FFP replacement. |
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