Regional cerebral blood flow change in a case of Alzheimer's disease with musical hallucinations |
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Authors: | T. Mori MD M. Ikeda MD PhD R. Fukuhara MD PhD Y. Sugawara MD PhD S. Nakata RT N. Matsumoto MD P. J. Nestor PhD FRACP H. Tanabe MD PhD |
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Affiliation: | (1) Department of Neuropsychiatry, Ehime University School of Medicine, Toon city, Ehime 791-0295, Japan;(2) Department of Radiology, Ehime University School of Medicine, Toon city, Ehime 791-0295, Japan;(3) University of Cambridge Neurology Unit, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK |
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Abstract: | We examined alteration of regional cerebral blood flow (rCBF) in a case of Alzheimer's disease (AD) patient with musical hallucination. To detect regions related to musical hallucination, single–photon emission computed tomography (SPECT) imaging of the patient and nine sex, age, and cognitive functionmatched AD patients without delusions and hallucinations were compared using statistical parametric mapping 99 (SPM99). In comparison with controls, the patient had increased rCBF in left temporal regions and left angular gyrus. This profile could be relevant to the neuroanatomical basis of musical hallucinations. This work had been carried out at the Higher Brain Function Clinic of the Ehime University Hospital. |
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Keywords: | single– photon emission computed tomography regional cerebral blood flow musical hallucination Alzheimer's disease superior temporal gyrus |
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