Electron microscopic study of signet-ring cells in diffuse carcinoma of the human stomach |
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| Authors: | Kazuo Yamashiro MD Harumi Suzuki Takeo Nagayo |
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| Institution: | (1) The Laboratory of Pathology, Aichi Cancer Center, Research Institute, Chikusa-ku, 464 Nagoya, Japan;(2) The 2nd Depertment of Surgery, Kumamoto University School of Medicine, Honjo 1-chome, 860 Kumamoto, Japan |
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| Abstract: | Summary The signet-ring cells seen in gastric carcinoma of the diffuse type were studied by light and electron microscopy. A classification of these cells into Types A, B and C was developed, based on intracellular mucous granules, nuclei and organelles, and by reactions to PAS and Alcian-blue staining. The gradual transition of Type A cells to Type B and the subsequent change of Type B to Type C suggest successive stages in maturation. These cells, especially those of Type B, resemble the mucous neck cells of the corpus and the glands of the pylorus. |
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| Keywords: | Signet-ring cell Scirrhous carcinoma Gastric carcinoma Electron microscopy Stomach cancer |
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