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| 多发性肌炎与皮肌炎并发肺间质病变与抗Jo-1抗体的关系 | |
| 引用本文： | 吴秀琳,郭华,张巧,钱桂生,方勇飞. 多发性肌炎与皮肌炎并发肺间质病变与抗Jo-1抗体的关系[J]. 重庆医学, 2011, 40(19): 1899-1900,1903. DOI: 10.3969/j.issn.1671-8348.2011.19.010 |
| 作者姓名： | 吴秀琳 郭华 张巧 钱桂生 方勇飞 |
| 作者单位： | 哈尔滨医科大学研究生学院,150081;重庆武警总队医院呼吸科,400061;第三军医大学新桥医院呼吸内科,重庆,400037;第三军医大学西南医院中医科,重庆,400038 |
| 摘 要： | 目的通过研究多发性肌炎(PM)和皮肌炎(DM)合并肺间质病变(ILD)患者的临床特点及其与抗Jo-1抗体的关系,探讨如何减少误诊和漏诊。方法回顾性对比分析抗Jo-1抗体阳性36例和阴性118例PM/DM患者,比较两组首发症状、临床及免疫学特征。结果抗Jo-1抗体阳性组以呼吸道症状首发者明显高于阴性组(52.8%vs 3.4%,P<0.05),伴发肺部感染、多关节炎、发热等症状多,RF阳性率较高,与抗R0-52、抗SSA/SSB相关性较强,检出率较高,易误诊或漏诊。部分PM/DM合并ILD患者仅有呼吸困难症状易误诊为心衰、特发性肺间质纤维化、肺部感染等疾病,而部分患者却因无相关呼吸系统症状而漏诊ILD。结论 PM/DM或肺间质性病变患者,均需积极完善包括抗Jo-1抗体的抗核抗体谱、肌酶谱的检测及高分辨螺旋CT、肺功能等检查,以减少误诊和漏诊。 |
| 关 键 词： | 多发性肌炎 皮肌炎 抗Jo-1抗体 肺间质病变 |
Polymyositis and dermatomyositis associated interstitial lung disease and anti-jo-1 antibody |
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| Wu Xiulin,Guo Hua,Zhang Qiao,Qian Guisheng,Fang Yongfei. Polymyositis and dermatomyositis associated interstitial lung disease and anti-jo-1 antibody[J]. Chongqing Medical Journal, 2011, 40(19): 1899-1900,1903. DOI: 10.3969/j.issn.1671-8348.2011.19.010 | |
| Authors: | Wu Xiulin Guo Hua Zhang Qiao Qian Guisheng Fang Yongfei |
| Affiliation: | Wu Xiulin1,Guo Hua2,Zhang Qiao3,Qian Guisheng3,Fang Yongfei4(1.Postgraduate College,Harbin Medical Unirersity 150081,China,2.Department of Respiratory Medicine,Chongqing Corps Hospital of Chinese Armed Police Forces,Chongqing 400061,3.Institute of Respiratory Medicine,Third Military Medical University Affiliated Xinqiao Hospital,Chongqing 400037,4.Department of Traditional Chinese Medicine,Southwest Hospital,Third Military Medical University,Chongqing 400038,China) |
| Abstract: | Objective To investigate the clinical characteristics of polymyositis(PM)and dermatomyositis(DM)associated interstitial lung disease(ILD)and relationship with anti-jo-1 antibody,to explore how to reduce the misdiagnosis and missed.Methods Retrospective comparison and analysis of the first symptoms,clinical and immunologic features were performed between 36 PM/DM with anti-jo-1 antibody-positive patients and 118 patients with antibody-negative.Results The first symptom come from respiratory tract in antibody... |
| Keywords: | poiymyositis dermatomyositis anti-jo-1 antibody interstitial lung disease |
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