阴沟肠杆菌98例的临床分布特点和耐药性分析

目的了解阴沟杆菌的临床分布情况及耐药性,为临床合理使用抗生素提供依据。方法对医院近4年内临床上分离出的阴沟肠杆菌的临床分布特点及耐药情况进行回顾性分析。结果 2007年1月至2010年12月,4年期间共检出98株阴沟肠杆菌,菌株分布于多个病区;标本来源以痰及咽拭子(75.5%)为主;药敏结果显示阴沟肠杆菌对亚胺培南的敏感率最高,为100%,其次是阿米卡星和奈替米星,分别为91.8%和85.7%;阴沟肠杆菌对阿莫西林和头孢噻吩均为100%耐药。结论阴沟肠杆菌是临床感染性疾病的常见病原菌之一,其耐药率较高,合理选择抗菌药物要以药敏实验为依据。

Distribution features and drug resistance analysis of 98 isolates of Enterobacter cloacae

Objective The clinical distribution and drug resistance of infections caused by Enterobacter cloacae （ E. cloacae） were investigated in our hospital to provide evidence for the rational use of antibiotics. Methods Retrospective analysis of the drug resistance situation and clinical specimen distribution was made to E. cloaca isolated from our hospital in the recent 4 years. Results Totally 98 isolates of E. cloaca were isolated between Jan 2007 and Nov 2010 with 75% isolated from sputum. The 98 E. cloaca isolates distributed in many wards of the hospital. 100% of isolates were sensitive to imipenem, 91.8% to amikacin and 85.7% to netilmicin. The drug resistance to amoxicillin and cafalotin was highest in all antibacterial. The rate of drug resistance was 100%. Conclusion E. cloaca is one of the common pathogens resulting in nosocomial infections. The study indicates that E. cloaca isolates display high drug - resistance and the selection of antibiotics should be based on the results of drug sensitivity tests.