|
|||||
|
|
| CYP2D6与他莫昔芬疗效相关性的研究进展 | |
| 引用本文： | 雷蕾,王晓稼. CYP2D6与他莫昔芬疗效相关性的研究进展[J]. 癌症进展, 2009, 7(1): 62-65,55 |
| 作者姓名： | 雷蕾 王晓稼 |
| 作者单位： | 浙江中医药大学附属肿瘤医院肿瘤内科,杭州,310022;浙江中医药大学附属肿瘤医院肿瘤内科,杭州,310022 |
| 基金项目： | 中国女性乳腺癌CYP2D6基因多态性与三苯氧胺代谢及疗效相关性研究（2008B020） |
| 摘 要： | CYP2D6是一种重要的P450系氧化代谢酶，是他莫昔芬在体内代谢成更强抗雌激素作用代谢产物endoxifen的重要代谢酶，因此，强代谢乳腺癌患者服用他莫昔芬后引起明显的潮热症状，而潮热症状的发生与他莫昔芬疗效正相关。除了CYP2D6基因多态性可能影响他莫昔芬体内的代谢外，帕罗西汀（paroxetine）可竞争性抑制CYP2D6对他莫昔芬的代谢，使乳腺癌患者对他莫昔芬疗效明显降低。 |
| 关 键 词： | CYP2D6 基因多态性 他莫昔芬 乳腺癌 |
Advances in correlation between CYP2D6 and tamoxifen therapy |
|
| Lei Lei,Wang Xiaojia. Advances in correlation between CYP2D6 and tamoxifen therapy[J]. Oncology Progress, 2009, 7(1): 62-65,55 | |
| Authors: | Lei Lei Wang Xiaojia |
| Affiliation: | (Department of Medical Oncology, Cancer Hospital, Zhejiang Chinese Medical University, Hangzhou 310022, China) |
| Abstract: | CYP2D6 is an important P450 cytochrome oxidases. It is the key enzyme in the transformation of tamoxifen to endoxifen, which has stronger anti-estrogen effect. Therefore, extensive metabolizers tend to have obvious hot flashes after tamoxifen treatment, which is positively correlated with the outcome of tamoxifen. CYP2D6＇s polymorphyism may influence the endo-metabolism of tamoxifen, and paroxetine may remarkably decrease the efficacy of tamoxifen by competitively inhibiting CYP2D6. |
| Keywords: | CYP2D6 |
| 本文献已被 维普 万方数据 等数据库收录！ | |