首发与复发抑郁症患者静息态下脑局部一致性差异的功能磁共振成像研究

目的 探讨静息态下重性抑郁症首发与复发患者的脑功能特点及其差异.方法 首发与复发抑郁患者各14例及15例健康者参加磁共振扫描.结果 较健康组,首发抑郁组右额下回、左颞上回、左颞中回、左颞下回、左前扣带回腹侧、右后扣带回、左海马、左海马旁回、左尾状核、左豆状核及左屏状核局部一致性(ReHo值)减低,而右梭状回ReHo值增高;复发抑郁组双侧额上回、双侧额中回、左额下回、左颢上回、左颞中回、左颢下回、双侧后扣带回、左海马及左海马旁回ReHo值减低,而左缘上回ReHo值增高.复发较首发抑郁组左颞中回、左颞下回及右眶额皮质ReHo值增高,而右额中回、右楔前叶、右后扣带回及右海马旁回ReHo值减低.结论 首发与复发抑郁患者脑功能均存在异常,两者的异常有共同点,也有各自特征,且首发与复发患者脑功能存在明显差异.

Regional homogeneity difference between first-episode and recurrent depressed patients: a resting-state fMRI study

Objective To explore the features of the brain function in first-episode and recurrent major depressed patients and their differences. Methods 14 first-episode depressed patients, 14 recurrent depressed patients and 15 healthy subjects experienced the MRI scans. Results Compared with healthy group, the first-episode depressed group showed significantly decreased regional homogeneity ( ReHo) in the right inferior frontal gy-rus,left superior,middle,inferior temporal gyrus, left ventral anterior cingulate gyrus,right posterior cingulate gyms, left hippocampus, left parahippocampal gyrus,left caudate,left lentiform and left claustrum,and increased ReHo in the right fusiform gyrus;the recurrent depressed group showed significantly decreased ReHo in the bilateral superior frontal gyrus, bilateral middle frontal gyrus, left inferior frontal gyrus, left superior, middle, inferior temporal gyrus, bilateral posterior cingulate gyrus, left hippocampus and left parahippocampal gyrus, and increased ReHo in the left supramarginal gyrus. Compared with first-episode depressed group, the recurrent depressed group showed significantly decreased ReHo in the right middle frontal gyrus, right precuneus, right posterior cingulate gyrus and right parahippocampal gyrus, and increased ReHo in the left middle, inferior temporal gyrus and right orbitofrintal cortex. Conclusions This study suggests abnormal brain activity may be distributed extensively in both first-episode and recurrent depressed patients. Their abnormality have some common features, also have each independent features. There are significant differences in brain function between first-episode and recurrent depressed patients.