Impact of type 2 diabetes mellitus on diffuse inflammatory activation of de novo atheromatous lesions: Implications for systemic inflammation |
| |
Authors: | K Toutouzas E Tsiamis M Drakopoulou A Synetos J Karampelas M Riga C Tsioufis D Tousoulis E Stefanadi C Vlassis C Stefanadis |
| |
Institution: | aFirst Department of Cardiology, Athens Medical School, Hippokration Hospital, 24, Karaoli and Dimitriou street, 15562 Holargos, Athens, Greece;bDepartment of Anatomy, Athens Medical School, 15562 Holargos, Athens, Greece |
| |
Abstract: | AimsLocal coronary and systemic inflammation is pronounced in patients with diabetes mellitus (DM). Intracoronary thermography detects local inflammation and C-reactive protein (CRP) is a marker of systemic inflammation. We investigated whether or not, in patients with DM, thermal heterogeneity of culprit lesions (CLs) correlates with that of non-culprit lesions (NCLs) and with systemic inflammation.MethodsWe included DM patients who had two angiographically significant lesions and were undergoing percutaneous coronary intervention. We measured the temperature difference (ΔT) between the lesion and proximal vessel wall.ResultsWe included 104 (n = 208 lesions) patients: 32 (n = 64 lesions) had DM and 72 (n = 144 lesions) were non-DM (control group). ΔT was increased in DM in both CLs and NCLs (CLs: DM = 0.12 ± 0.06 °C; no DM = 0.06 ± 0.04 °C; P < 0.01 versus NCLs: DM = 0.13 ± 0.08 °C versus no DM = 0.06 ± 0.05 °C; P < 0.01). Patients with DM had similar ΔT in CLs and NCLs (P = 0.49). A linear correlation was detected between heat production in all lesions and CRP (R = 0.45; P < 0.01), which was attributed to the correlation of ΔT in lesions of patients with DM and CRP (R = 0.32; P < 0.01). In lesions of patients with low CRP, a greater rate of discrepancy was found, as 100% of lesions in patients with DM versus 66.1% of lesions of patients without DM had a high ΔT in one or both lesions (P < 0.01).ConclusionIn patients with DM, local inflammatory activation is diffuse and correlates with systemic inflammation. However, low systemic inflammatory activation does not always predict an increase in local thermal heterogeneity. |
| |
Keywords: | Diabetes mellitus Inflammation Atherosclerosis Intracoronary thermography CRPMots clé s: Diabè te sucré Inflammation Athé rosclé rose Thermographie endocoronaire CRP |
本文献已被 ScienceDirect 等数据库收录! |
|