| 苯环利定致大鼠心肌损伤的研究 |
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| 引用本文： | 石刚刚,许绍芬. 苯环利定致大鼠心肌损伤的研究[J]. 复旦学报(医学版), 1994, 0(4) |
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| 作者姓名： | 石刚刚 许绍芬 |
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| 作者单位： | 上海医科大学基础医学院神经生物学教研室医学神经生物学实验室 |
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| 基金项目： | 卫生部科研基金,国家教委博士点基金 |
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| 摘 要： | 作者观察了苯环利定（ＰＣＰ）注入大鼠静脉内可以造成急性心肌损害的心电图变化，即Ｔ波明显抬高；而侧脑室注入ＰＣＰ，在２ｈ内未见这种变化，提示ＰＯＰ致大鼠心肌损害主要通过外周作用。经典扩冠药硝酸甘油和对ＰＣＰ受体具有拮抗作用的氟哌啶醇均完全阻断ＰＣＰ所致的心电图改变，提示ＰＣＰ造成大鼠心肌损伤可能是由于冠脉收缩所致，氟哌啶醇对抗冠状动脉的收缩有一定的作用。
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| 关 键 词： | 苯环利定，心电图，硝酸甘油，氟哌啶醇，侧脑室注射 |
STUDY ON HEART INJURY INDUCED BY PHENCYCLIDINE IN RATS |
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| Shi Ganggang,Xu Shaofen. STUDY ON HEART INJURY INDUCED BY PHENCYCLIDINE IN RATS[J]. Fudan University Journal of Medical Sciences, 1994, 0(4) |
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| Authors: | Shi Ganggang Xu Shaofen |
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| Abstract: | The present study was designed to observe changes of electrocardiogram (ECG)of acute heart injury induced by intravenous phencyclidine (PCP). The results showed that T wave rose evidently after intravenous PCP,however there was no any change after intraeerebroventriclar injection of PCP for 2 hours.The results suggested that the site of PCP action was mainly through peripheral.Nitroglycerine,a drug of coronary vasodilation,and haloperidol,an antagonist of PCP receptor,both blocked the changes in ECG induced by PCP fully.The results indicated that heart injury induced by PCP may be mediated by contraction of coronary artery in rats,and haloperidol may possess effect against contraction of coronary artery. |
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| Keywords: | phencyclidine ECG nitroglycerine haloperidol intracere-broventriclar injection |
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