影响血清甲状腺球蛋白水平因素的流行病学研究

目的 研究不同因素对≥14周岁人群血清甲状腺球蛋白(TG)水平的影响。方法 选择碘缺乏、碘充足和碘过量的3个农村社区,测定3地区甲状腺球蛋白抗体(TGAb)阴性的3335例居民的血清TG、促甲状腺激素(TSH)水平和甲状腺体积(B超法)。结果 在尿碘中位数(MUI)80—650μg/L人群中,血清TG浓度呈现一个V型变化,即碘缺乏和碘过量状态都可以导致血清TG的升高;血清TSH浓度与血清TC浓度也呈现V型的关系,即血清TSH低于0．3mU／L时,血清TG显著升高;血清TSH高于4．8mU／L时,血清TG也显著升高;甲状腺的体积与血清TG的水平呈现明显正相关的关系;女性的血清TG浓度显著高于男性;年龄对血清TG的影响仅发生在碘缺乏地区,50岁以上人群的血清TG水平显著增高。结论 性别、碘摄入量、血清TSH浓度和甲状腺体积因素影响血清TG浓度。

An epidemiological study on factors affecting serum thyroglobulin levels

OBJECTIVE: To investigate the effects of several factors affecting serum thyroglobulin (TG) levels among people aged 14 or more. METHODS: We selected Panshan with median urinary iodine (MUI) 83.45 micro g/L as a deficient iodine intake community, Zhangwu with MUI 242.85 micro g/L as a sufficient iodine intake community and Huanghua with MUI 650.87 micro g/L as an excessive iodine intake community. Serum TG and thyroid stimulating hormone (TSH) were measured in 3,335 subjects whose thyroglobulin antibody (TGAb) were negative and thyroid volume were examined using B-ultrasound. RESULTS: In the population with MUI of 80 - 650 micro g/L, serum TG levels presented a "V" curve. An elevated serum TG was found in both the communities with deficient iodine intake and excessive iodine intake. The same trend was shown in the groups with different levels of serum TSH. An elevated serum TG was found in both the groups of TSH < 0.3 mU/L and TSH > 4.8 mU/L. The serum TG levels was positively correlated with thyroid volume and was higher in female subjects than in male. An increased serum TG was found in subjects of aged 50 in the community with deficient iodine intake. CONCLUSION: Serum TG level is affected by gender, amount of iodine intake, serum TSH level and thyroid volume.