腹腔镜手术联合药物在中重度子宫内膜异位症诊治中的应用

目的:探讨腹腔镜联合药物治疗中重度子宫内膜异位症的效果。方法:选择2003年12月至2006年12月确诊为子宫内膜异位症的患者98例,术前半年内未用过激素治疗,肝、肾功能正常,无心肺疾患。随机分为对照组50例,腹腔镜手术+米非司酮;研究组48例,腹腔镜手术+孕三烯酮。腹腔镜下进行病变分期,术后随访12~36个月,观察各组有效率、术后复发率、术后妊娠率及血CA125水平变化、肝、肾功能变化。结果:对照组有效率60.0%,研究组有效率84.3%,研究组疼痛症状和体征完全缓解率高于对照组,复发率低于对照组,两组比较差异有统计学意义(P<0.05)。对照组术后10个月内复发5例,均为中重度患者,且病情复发程度与血CA125水平升高呈相关性,经服用孕三烯酮后病情得到控制。研究组复发2例,均发生在术后12个月以后,为重度患者,经再次服用孕三烯酮后病情得到控制。研究组于术后服药后出现闭经32例,停药后2~3个月月经恢复,无痛经及性交痛。对照组闭经48例、子宫内膜过度增生1例,停药后半年内恢复月经。结论:孕三烯酮及米非司酮均可作为中重度子宫内膜异位症腹腔镜术后的控制用药,因其服药方便、有效、副作用少可用于广大患者,而孕三烯酮的服药效果明显优于米非司酮且不影响子宫内膜,对复发的子宫内膜异位症治疗仍然有效而备受偏爱。

The application of laparoscopic operation and drugs in diagnosing and treating endometriosis midrange and severe

Objective:To explore the effect of diagnosing and treating midrange and severe endometriosis with laparoscope and drugs.Methods:The 98 cases of endometriosis diagnosed with laparoscope from December 2003 to December 2006 were divided into two groups A and B.Group A was treated with mifepristone while group B with gestrione postoperatively.The rate of effect,relapse and pregnancy operatively,level of CA125,function of liver and kidney were compared during the following up of 12 to 36 months.Results:The effect rate of group A and B is 60.0% and 84.3%.The relapse rate of group B is lower than group A.There are significant difference between the two groups(P<0.05).Conclusions:Mifepristone and gestrione are both effective in treating midrange and severe endometriosis after laparoscopic operation.Mifepristone is better than gestrione with no influence on endometrium and effect on relapse endometriosis.