134例老年肺结核患者痰结核菌耐药情况分析

目的探讨老年肺结核患者痰结核菌的耐药情况。方法采用ＢＡＣＴＥＣ法对１３４例老年痰菌阳性肺结核患者痰结核分支杆菌做耐药性检测。结果老年肺结核患者初始耐药率为３６８％，显著低于获得性耐药率的７５９％（Ｐ＜００１）；耐异烟肼（ＩＮＨ，Ｈ）、利福平（ＲＦＰ，Ｒ）、链霉素（ＳＭ，Ｓ）前者亦明显低于后者（Ｐ＜００１）。初治组耐２和３种药比例为６６％和５３％，与复治组的２２４％和２７７％相比差异有显著性（Ｐ＜００１）。至少耐异烟肼和利福平两种药的比例，初治组为９２％，显著低于复治组的５００％（Ｐ＜００１）。结论老年人肺结核耐药情况严重，尤其是获得性耐药和耐多药比例偏高，应引起足够重视

Drug resistance in 134 aged patients with pulmonary tuberculosis

Objective To determine resistance pattern to anti tuberculosis drugs in aged pulmonary tuberculosis patients. Methods Drug sensitivity test was carried out by BACTEC in 134 cases. Results Drug resistance was found in 36 8% of new cases, which was significantly lower than that (75 9%) of recurrent cases( P <0 01) and so did the resistance to isoniazid (INH), rifampin(RFP) and streptomycin (SM)( P <0 01). About 6 6% and 5 3% in new cases were resistant to two and three drugs, while 22 4% and 27 7% in recurrent cases ( P <0 01). Resistance to both INH and RFP at least in new cases was 9 2% and in recurrent cases was 50 0%( P <0 01). Conclusions This survey indicated that drug resistance in aged pulmonary tuberculosis patients was serious, especially the high acquired resistance and multi drug resistance.