43例白塞病临床特点及治疗分析

目的分析总结白塞病患者的临床特点、治疗情况以提高对白塞病的认识。方法收集43例白塞病住院患者的临床资料,回顾性分析其人口参数、临床表现、系统受累、治疗情况等。结果患者平均发病年龄（39.1±13.0）岁,病程（3.0±2.8）年。复发性口腔溃疡100%,其次为生殖器溃疡55.8%,结节红斑48.8%,假性毛囊炎41.9%,眼部病变37.2%,关节炎/关节痛34.9%,消化道、心脏受累发生率分别为16.3%与9.3%。针刺反应阳性率为34.9%。8例分别有肺结核感染、慢性乙型肝炎及生殖器疱疹继发感染。35例患者均应用剂量不等的糖皮质激素治疗（泼尼松5 mg qd～260 mg qd）,43例患者中28例分别应用了不同的免疫抑制剂治疗如反应停、秋水仙碱、硫唑嘌呤、雷公藤、柳氮磺吡啶及爱若华等,无患者应用生物制剂。结论白塞病临床表现复杂,可累及多个系统,重症患者预后不佳。针对器官系统损害的治疗需进一步规范化。

Clinical characteristics and treatment analysis for 43 cases with Behcet's disease

Objective To sum up clinical characteristics of in-patients with Behcet's disease,so to improve our knowledge about it.Methods Clinical data of 43 cases with Behcet's disease admitted to Anhui Provincial Hospital were collected.Their population parameters,clinical manifestations,system involvement and treatment were analyzed retrospectively.Results Mean age at onset was(39.1±13.0) years with an average course of(3.0±2.8) years.Oral ulcer(aphtha) was found in all the 43(100%) patients,and then followed by genital ulcer(55.8%),erythema nodosa(48.8%),pseudo-folliculitis(41.9%),inflammatory ocular disease(37.2%),arthralgia/arthritis(34.9%).Gastro-intestine and heart were also involved in these patients at the frequency of 16.3% and 9.3% respectively.34.9% patients presented positive pathergy test.8 cases had tuberculosis infection and chronic hepatitis B and genital herpes secondary infection.35 cases of patients were treated by different doses of glucocorticoid.Cases of patients received immunosuppressive treatment,including thalidomide,colchine,azathioprine,tripterygium glycosides,sulfasalazine and leflunomidewithout any biological agent.Conclusion Multiple organs and systems could be involved in Behcet's disease with diversity of clinical manifestations.The treatment for systemic lesion should be further standardized.