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Psychosis as a predictor of response to lithium maintenance treatment in bipolar affective disorder |
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| Authors: | Norman E. Rosenthal Leora N. Rosenthal Frank Stallone Joseph Fleiss David L. Dunner Ronald R. Fieve |
| Affiliation: | 1. Chief Resident, New York State Psychiatric Institute, USA;2. Graduate Student, Columbia University, USA;3. Ayerst Laboratories, Inc., USA;4. Professor and Head, Division of Biostatistics, School of Public Health, Columbia University, USA;5. Associate Director, Lithium Clinic, New York State Psychiatric Institute, and Associate Professor of Clinical Psychiatry at Columbia University College of Physicians and Surgeons, USA;6. Professor of Clinical Psychiatry at Columbia University College of Physicians and Surgeons and Chief of Psychiatric Research for Lithium Clinic at New York State Psychiatric Institute, New York, NY 10032, U.S.A. |
| Abstract: | Sixty-six bipolar I lithium clinic patients were studied for a history of psychotic symptoms at some time during the course of their illness. Agreement between different sources of information was calculated, and the patient population was divided into psychotic and non-psychotic subgroups. Probability of remaining well on lithium for the different subgroups was analyzed by the life table method. Psychosis during mania appeared to be associated with especially good early lithium prophylaxis. |
| Keywords: | All correspondence should be addressed to: Norman E. Rosenthal M.D. Staff Fellow Clinical Psychobiology Branch National Institute of Mental Health Building 10 Room 4S239 9000 Rockville Pike Bethesda MD 20205 U.S.A. |
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