| 3,3-二(二苄氧膦酰基)丙酸和3,3-二(二苄氧膦酰基)丙醇的合成 |
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| 引用本文： | 黄娟,郭子维,陈慧,曾建成,吴勇. 3,3-二(二苄氧膦酰基)丙酸和3,3-二(二苄氧膦酰基)丙醇的合成[J]. 华西药学杂志, 2004, 19(1): 6-8 |
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| 作者姓名： | 黄娟 郭子维 陈慧 曾建成 吴勇 |
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| 作者单位： | 四川大学华西药学院,四川,成都,610041;四川大学华西医院,四川,成都,610041 |
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| 基金项目： | 国家自然科学基金资助项目 (批准号 :3 9970 869、3 0 2 0 0 2 86 |
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| 摘 要： | 目的 合成3，3-二(二苄氧膦酰基)丙酸(5)和3，3-二(二苄氧膦酰基)丙醇(6)。方法以亚甲基偕二膦酸四乙酯(1)为原料经水解、氯膦酰化、酯化、缩合得3，3-二(二苄氧膦酰基)丙酸(5)，随后选择性硼氢化还原得3，3-二(二苄氧膦酰基)丙醇(6)。结果化合物(5)、(6)的结构经IR、^1HNMR和质谱确证。结论所用方法合成3，3-二(二苄氧膦酰基)丙酸(5)和3，3-二(二苄氧膦酰基)丙醇(6)较理想。
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| 关 键 词： | 化学合成 3 3-二(二苄氧膦酰基)丙酸 3-二(二苄氧膦酰基)丙醇 |
| 文章编号： | 1006-0103(2004)01-0006-03 |
| 修稿时间： | 2003-09-01 |
Synthesis of 3,3-bis(dibenzyloxyphosphoryl)propionic acid and 3,3-bis(dibenzyloxyphosphoryl)propanol |
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| HUANG Juan ,GUO Zi-wei ,CHEN Hui ,ZENG Jian-cheng ,WU Yong. Synthesis of 3,3-bis(dibenzyloxyphosphoryl)propionic acid and 3,3-bis(dibenzyloxyphosphoryl)propanol[J]. West China Journal of Pharmaceutical Sciences, 2004, 19(1): 6-8 |
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| Authors: | HUANG Juan GUO Zi-wei CHEN Hui ZENG Jian-cheng WU Yong |
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| Affiliation: | HUANG Juan 1,GUO Zi-wei 1,CHEN Hui 1,ZENG Jian-cheng 2,WU Yong 1* |
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| Abstract: | OBJECTIVE To synthesize 3,3-bis(dibenzyloxyphosphoryl)propionic acid(5) and 3,3-bis(dibenzyloxyphosphoryl)propanol(6).METHODS 3,3-bis(dibenzyloxyphosphoryl) propionic acid (5) and (6) were synthesized from tetraethyl methylene bisphosphonate via hydrolysis,chlorination of the acid,esterification,condensation,then 3,3-bis (dibenzyloxyphosphoryl)propanol (6) was obtained via selective reduction of (5).RESULTS The structure of compounds (5) and (6) were confirmed by IR, 1HNMR and MS.CONCLUSION This method is a better method to synthesize compounds (5) and (6). |
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| Keywords: | Chemical synthesis 3 3-bis(dibenzyloxy phosphoryl)propionic acid 3 3-bis (dibenzyloxyphosphoryl)propanol |
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