| 附子不同炮制品对麻黄细辛附子汤煎剂质量的影响 |
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| 引用本文： | 邱丽丽,李灿,范珊珊,韩旭,杨勇,容蓉.附子不同炮制品对麻黄细辛附子汤煎剂质量的影响[J].中国实验方剂学杂志,2018,24(10):1-7. |
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| 作者姓名： | 邱丽丽 李灿 范珊珊 韩旭 杨勇 容蓉 |
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| 作者单位： | 山东中医药大学山东省经方研究重点实验室中医药抗病毒协同创新中心;胜利油田中心医院 |
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| 基金项目： | 国家自然科学基金项目（81774167）；山东省重点产业关键技术创新工程项目（2016CYJS08A01-5） |
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| 摘 要： | 目的:比较不同附子炮制品制备所得麻黄细辛附子汤(MXF)的质量差异,探析经方中炮制品规格选用的科学性。方法:采用临床常用的5种附子炮制品规格分别制备MXF煎剂,选取MXF中具有效毒二重性的化学成分为评价指标,考察不同附子炮制品对MXF煎剂中效毒成分含量的影响。结果:建立了MXF中13种指标成分的含量测定方法。采用多元统计分析筛选出区别附子不同炮制品制备所得煎剂的指标性成分有卡枯醇、甲基丁香酚、细辛脂素、新乌头碱、次乌头碱和乌头碱。与附子的其他炮制品规格相比,炒附片制备所得煎剂中,双酯型生物碱类成分的含量较低但其单酯型生物碱类成分的含量最高。结论:附子不同炮制品制备所得MXF煎剂中效毒成分的含量存在较大差异,可为经方的古为今用提供参考。
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| 关 键 词： | 麻黄细辛附子汤 附子 炮制品 效毒成分 煎剂 双酯型生物碱 麻黄生物碱 |
| 收稿时间： | 2017/11/4 0:00:00 |
Effect of Different Processed Products of Aconiti Lateralis Radix Praeparata on Quality of Mahuang Xixin Fuzitang |
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| QIU Li-li,LI Can,FAN Shan-shan,HAN Xu,YANG Yong and RONG Rong.Effect of Different Processed Products of Aconiti Lateralis Radix Praeparata on Quality of Mahuang Xixin Fuzitang[J].China Journal of Experimental Traditional Medical Formulae,2018,24(10):1-7. |
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| Authors: | QIU Li-li LI Can FAN Shan-shan HAN Xu YANG Yong and RONG Rong |
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| Institution: | Collaborative Innovation Center of Antivirus of Traditional Chinese Medicine(TCM), Shandong Key Laboratory of Classic Chinese Materia Medica Recipe, Shandong University of TCM, Ji''nan 250355, China;Shengli Oilfield Central Hospital, Dongying 257034, China,Collaborative Innovation Center of Antivirus of Traditional Chinese Medicine(TCM), Shandong Key Laboratory of Classic Chinese Materia Medica Recipe, Shandong University of TCM, Ji''nan 250355, China,Collaborative Innovation Center of Antivirus of Traditional Chinese Medicine(TCM), Shandong Key Laboratory of Classic Chinese Materia Medica Recipe, Shandong University of TCM, Ji''nan 250355, China,Collaborative Innovation Center of Antivirus of Traditional Chinese Medicine(TCM), Shandong Key Laboratory of Classic Chinese Materia Medica Recipe, Shandong University of TCM, Ji''nan 250355, China,Collaborative Innovation Center of Antivirus of Traditional Chinese Medicine(TCM), Shandong Key Laboratory of Classic Chinese Materia Medica Recipe, Shandong University of TCM, Ji''nan 250355, China and Collaborative Innovation Center of Antivirus of Traditional Chinese Medicine(TCM), Shandong Key Laboratory of Classic Chinese Materia Medica Recipe, Shandong University of TCM, Ji''nan 250355, China |
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| Abstract: | Objective: To compare the quality difference between Mahuang Xixin Fuzitang (MXF) prepared by different processed products of Aconiti Lateralis Radix Praeparata for exploring the scientificalness of selection of processed products specification in classic Chinese materia medica recipe. Method: By taking effect-toxic components in MXF as evaluation indexes, this article investigated MXF decoction prepared by five different processed products of Aconiti Lateralis Radix Praeparata from the quantitative determination of effect-toxic components in MXF. Result: After multivariate statistical analysis, six characteristic constituents were identified as kakuol, methyl eugenol, asarinin, mesaconitine (MA), hypaconitine (HA) and aconitine (AC), respectively.Compared with other processed products, the processed product prepared by stir-frying had the lower content of diester alkaloids and the highest level of monoester alkaloids. Conclusion: There are differences on the content of effect-toxic components in MXF prepared by different processed products of Aconiti Lateralis Radix Praeparata, which can provide a reference for making the past serve the present of classic Chinese materia medica recipe. |
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| Keywords: | Mahuang Xixin Fuzitang Aconiti Lateralis Radix Praeparata processed products effect-toxic components decoction diester alkaloids alkaliods in Ephedrae Herba |
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