下瘀血汤抗肝纤维化作用及其机制研究进展

肝纤维化是机体对多种慢性损伤的一种复杂修复应答,是诸多慢性肝病共有的病理变化,细胞外基质过度沉积和肝星状细胞活化被认为是其主要的发病机制,抗肝纤维化治疗已成为当前慢性肝脏疾病研究的焦点之一。下瘀血汤出自《金匮要略》,由大黄、桃仁、土鳖虫3味中药组成,现代中医临床用其治疗肝纤维化与肝硬化,取得了较好的临床疗效。本文拟对近年来下瘀血汤抗肝纤维化作用及其机制的研究进行总结,发现该经典名方通过抑制肝星状细胞活化和诱导活化的肝星状细胞凋亡、调控巨噬细胞功能、抑制肝窦毛细血管化及抗脂质过氧化等途径发挥抗肝纤维化作用,对该方在肝纤维化方面的新药研发及临床应用具有参考意义。

Research Progress of Anti-hepatic Fibrosis of Xiayuxue Tang and Its Mechanism

Hepatic fibrosis is a repair response to various chronic liver injuries.It is also a common pathological process of various chronic liver diseases.The excessive deposition of extracellular matrix and activation of hepatic stellate cells(HSCs) are currently considered to be the main factors in the complex pathogenesis of hepatic fibrosis.Thus, anti-hepatic fibrosis has become one of the focuses on treatment research of chronic liver diseases.Xiayuxue Tang was first recorded in the book of Jinkui Yaolue (Synopsis of the Golden Chamber), and was consisted of three Chinese medicinal herbs, Rhei Radix et Rhizoma, Persicae Semen, and Eupolyphaga Steleophaga.It has good clinical efficacy in the treatment of hepatic fibrosis and cirrhosis.This article was reviewed the study on the pharmacological effect and mechanism of anti-hepatic fibrosis of Xiayuxue Tang in recent years.It was found that Xiayuxue Tang exerts anti-hepatic fibrosis by inhibiting the activation of HSCs and inducing the apoptosis of activated HSCs, regulating the function of macrophage, inhibiting the capillarization of hepatic sinusoids and inhibiting the level of lipid peroxidation.And this article will help to the new drugs development and clinical treatment of Xiayuxue Tang in liver fibrosis.