| 人用狂犬病疫苗和被动免疫制剂研发进展 |
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| 引用本文： | 赖永洁,李靖. 人用狂犬病疫苗和被动免疫制剂研发进展[J]. 中国人兽共患病杂志, 2018, 34(6): 563-569. DOI: 10.3969/j.issn.1002-2694.2018.00.066 |
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| 作者姓名： | 赖永洁 李靖 |
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| 作者单位： | 1.遵义医学院珠海校区免疫学与病原生物学教研室,珠海 519041;2.珠海联邦制药股份有限公司,珠海 519041 |
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| 摘 要： | 狂犬病(Rabies)是由狂犬病毒(Rabies virus)引起的一种人兽共患病。人一旦发病致死率几乎100%。目前预防狂犬病的人用疫苗为狂犬病毒灭活疫苗。随着基因工程技术的进步,新一代以狂犬病毒G蛋白(Glycoprotein)为免疫原的疫苗在开发中,包括不同表达系统的G蛋白亚单位疫苗,G蛋白DNA疫苗,G蛋白病毒载体疫苗等。同时本文还探讨了未来可能取代狂犬病免疫球蛋白的被动免疫制剂(单克隆抗体)的研发进展。
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| 关 键 词： | 狂犬病 狂犬病毒 疫苗 G蛋白 单克隆抗体 |
| 收稿时间： | 2017-09-21 |
Research and development progress of human rabies vaccines and passive immune preparations |
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| LAI Yong-jie,LI Jing. Research and development progress of human rabies vaccines and passive immune preparations[J]. Chinese Journal of Zoonoses, 2018, 34(6): 563-569. DOI: 10.3969/j.issn.1002-2694.2018.00.066 |
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| Authors: | LAI Yong-jie LI Jing |
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| Affiliation: | 1. Department of Immunology and Pathogenic Biology, Zhuhai Campus, Zunyi Medical University, Zhuhai 519041, China;2. The United Laboratories (Zhuhai) Co., Ltd, Zhuhai 519041, China |
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| Abstract: | Rabies is a zoonotic disease caused by rabies virus. Rabies virus infection has a near 100% case fatality rate following the onset of clinical disease.Currently, vaccines used for rabies prevention in human are originated from inactivated rabies virus. With rapid development of gene engineering technology, new generation rabies vaccines using viral G protein (Glycoprotein) as antigen are in development, including sub-unit vaccines purified from different expression systems, DNA vaccines, and vaccines using viral vectors as carrier, etc. This review also discusses the research and development progress of the passive immune preparations (monoclonal antibodies) which could be an ideal substitute for rabies immunoglobulin in the future. |
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| Keywords: | rabies rabies virus vaccine G protein monoclonal antibody |
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