益肾通络方治疗慢性前列腺炎肾虚血瘀证的临床观察

目的:观察益肾通络方治疗慢性前列腺炎肾虚血瘀证的疗效及安全性。方法:将240例符合条件的患者随机分为中药组、西药组和联合组,各80例。分别给予益肾通络方,普适泰片,益肾通络方联合普适泰片,疗程均为2个月。观察治疗前后各组患者临床症状,检测血清炎症因子、血液流变学指标、前列腺液指标;比较各组患者总有效率,6个月随访复发率及不良反应发生率。结果:研究期间脱落7例。联合组总有效率97.5%,高于中药组的87.2%和西药组的84.2%(P0.05);中药组总有效率高于西药组,但差异无统计学意义。治疗后联合组患者临床症状、血清炎症因子、血液流变学指标、前列腺液指标较中药组和西药组明显改善(P0.05);中药组与西药组比较无统计学差异。随访复发率比较,联合组(3.4%)中药组(9.8%)西药组(17.9%)(P0.05)。不良反应发生率比较,中药组(1.3%)联合组(6.3%)西药组(17.1%)(P0.05)。结论:益肾通络方治疗慢性前列腺炎肾虚血瘀证安全有效,益肾通络方联合普适泰片具有增效减毒的作用。

Effect of Yishen Tongluo Fang in Treating Chronic Prostatitis Cause by Kidney Deficiency Blood Stasis

Objective: To explore the therapeutic effect and safety of Yishen Tongluo Fang in treatment of chronic prostatitis cause by kidney deficiency blood stasis. Method: A total of 240 eligible cases were randomly divided into the traditional Chinese medicine (TCM) group, the western medicine (WM) group and the TCM and WM group, with 80 cases in each group. The TCM group was treated with Yishen Tongluo Fang; the WM group was given prostat tablets; the TCM and WM group was provided with Yishen Tongluo Fang combined with prostat tablets, with a course of 2 months. The clinical symptoms, serum inflammatory factors, hemorheological indexes and prostatic fluid indexes in three groups were observed before and after treatment. The total effective rate was recorded, and the 6-month follow-up visits were paid to observe the recurrence rate and the adverse reactions. Result: Seven cases were shed during the study. The total effective rate was 97.5% in the TCM and WM group, which was higher than 87.2% in the TCM group and 84.2% in the WM group (P<0.05). The total effective rate in the TCM was higher than that in the WM group, without statistically significant difference. After treatment, the serum inflammatory factors, hemorheological indexes and prostatic fluid indexes in the TCM and WM group were higher than those in the WM group and the TCM group. There was no significant difference between the TCM group and the WM group. By the adverse reactions, the order from low to high was the TCM group (1.3%) < the TCM and WM group (6.3%) < the WM group (17.1%) (P<0.05). Conclusion: Yishen Tongluo Fang is safe and effective in the treatment of chronic prostatitis cause by kidney deficiency blood stasis. Its combination with prostat tablets has a synergistic effect and detoxification.