熟大黄的炮制、药效及临床应用研究进展

熟大黄具有缓和的泻下作用以及增强活血化瘀的功效,已被临床广泛应用于内科、外科等相关疾病的治疗,并且适用于老年体虚、婴幼儿、孕妇或慢性病长期服用的患者,具有宝贵的临床应用价值。而目前市售熟大黄因炮制工艺参数不明确,炮制过程的质量控制标识物不明确,造成市售熟大黄饮片质量参差不齐,从而影响临床的疗效。本文对熟大黄的炮制历史沿革、现代炮制工艺收载、药效物质研究、药效作用及临床应用情况进行综述,以期为熟大黄的后续炮制研究提供理论参考。

Advances in Processing,Pharmacodynamics and Clinical Application of Prepared Rhei Radix et Rhizoma

Prepared Rhei Radix et Rhizoma attenuated purgative activity and enhanced blood circulation.It was widely used in medical department,surgical department,department of pediatrics,department of obstetrics and gynecology,emergency departments and infectious diseases department.It was suitable for elderly patients with body deficiency,infants and young children,pregnant women or patients with chronic diseases,and it had valuable clinical application value.However,the quality of prepared Rhei Radix et Rhizoma in the market is uneven due to unclear processing parameters and quality control markers in the processing process,thus affecting the clinical efficacy.By referring to the related literature and books in recent years,this paper summarized the processing history,modern processing technology,pharmacodynamic material research,pharmacodynamic effect and clinical application of prepared Rhei Radix et Rhizoma,in order to provide theoretical reference for subsequent processing of this decoctiong pieces.