| 染色体多态性与男性不育的关系分析 |
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| 引用本文： | 张美华,盖凌,于建春,于小洁,张伟,张爱东. 染色体多态性与男性不育的关系分析[J]. 中国计划生育和妇产科, 2012, 0(2): 34-36 |
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| 作者姓名： | 张美华 盖凌 于建春 于小洁 张伟 张爱东 |
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| 作者单位： | 山东省计划生育科学技术研究所·山东省优生技术重点实验室 |
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| 摘 要： | 目的探讨染色体多态性与男性不育的关系。方法对297例临床诊断为少精子症、无精子症的男性不育患者按常规技术方法制备外周血染色体,并对染色体核型进行分析。结果 297例患者中有68例染色体核型异常,异常检出率为22.90%。其中,多态性变异12例,占异常核型的17.65%,包括次缢痕增长3例,9号染色体倒位2例,D/G组随体变异1例,Y染色体变异6例。结论染色体多态性与男性不育存在明显关系,不能忽视其临床效应。
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| 关 键 词： | 染色体多态性 男性不育 核型分析 |
The relationship between chromosomal polymorphism and male infertility |
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| ZHANG Mei-hua,GAI Ling,YU Jian-chun,YU Xiao-jie,ZHANG Wei,ZHANG Ai-dong. The relationship between chromosomal polymorphism and male infertility[J]. Chinese Journal of Family Planning & Gynecotokology, 2012, 0(2): 34-36 |
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| Authors: | ZHANG Mei-hua GAI Ling YU Jian-chun YU Xiao-jie ZHANG Wei ZHANG Ai-dong |
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| Affiliation: | Key Laboratory for Improving Birth Outcome Technique·Shandong Provincial Family Planning Institute of Science and Technology,Ji’nan Shangdong 250002,P.R.China |
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| Abstract: | Objective To explore the relationship between chromosomal polymorphism and male infertility.Methods Chromosome in peripheral blood from 297 oligospermia or azoospermia infertility patients were cultured and stained by G banding.Chromosomal karyotype of 297 cases were analyzed.Results The results showed abnormal karyotype in 68 cases among 297 oligospermia and azoospermia patients accounting for 22.89% in all subjects.Chromosomal polymorphism was 12 cases accounting for 17.65% in chromosome abnormalities.Among abnormalities,secondary constriction increasing were 3 cases,inversion of the ninth chromosomes were 2 cases,D/G set with body variant was 1 case and Y chromosome variation were 6 cases.Conclusion Chromosomal polymorphism is the main reason for male infertility so that the clinical effects can’t be ignored. |
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| Keywords: | chromosomal polymorphism male infertility karyotype analysis |
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