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| 磺胺甲噁唑在平原汉族、高原世居汉族和藏族健康人体的药物代谢动力学研究 | |
| 引用本文： | Li XY,Liu YN,Li YP,Yuan M,Zhu JB. 磺胺甲噁唑在平原汉族、高原世居汉族和藏族健康人体的药物代谢动力学研究[J]. 药学学报, 2011, 46(9): 1117-1122 |
| 作者姓名： | Li XY Liu YN Li YP Yuan M Zhu JB |
| 作者单位： | 青海大学医学院药学系; |
| 基金项目： | 国家自然科学基金资助项目(30460149,30960457) |
| 摘 要： | 探讨磺胺甲噁唑(SMZ)在平原汉族、高原世居汉族和藏族健康男性志愿者体内的药物代谢动力学特征。受试者口服复方新诺明片后,采用RP-HPLC法测定磺胺甲噁唑及其代谢产物N4-乙酰磺胺甲噁唑(N4-acetyl-SMZ)的血药浓度,DAS 2.0软件计算药物动力学参数。与平原志愿者比较,磺胺甲噁唑在高原世居汉族和藏族健康男性志愿者体内的药物代谢动力学发生显著变化,主要表现为半衰期延长、清除率降低。高原世居藏族的AUC0-∞显著小于高原世居汉族,其他药物代谢动力学参数无显著性差异。实验结果表明,在高原低氧环境中,磺胺甲噁唑的药物动力学特征发生显著改变。研究结果为高原世居汉族和藏族临床合理应用磺胺甲噁唑提供参考依据。 |
| 关 键 词： | 磺胺甲噁唑 药物动力学 平原 高原 汉族人 藏族人 |
Pharmacokinetics of sulfamethoxazole in healthy Han volunteers living at plain and in native Han and Tibetan healthy volunteers living at high altitude |
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| Li Xiang-yang,Liu Yong-nian,Li Yong-ping,Yuan Ming,Zhu Jun-bo. Pharmacokinetics of sulfamethoxazole in healthy Han volunteers living at plain and in native Han and Tibetan healthy volunteers living at high altitude[J]. Acta pharmaceutica Sinica, 2011, 46(9): 1117-1122 | |
| Authors: | Li Xiang-yang Liu Yong-nian Li Yong-ping Yuan Ming Zhu Jun-bo |
| Affiliation: | LI Xiang-yang,LIU Yong-nian,LI Yong-ping,YUAN Ming,ZHU Jun-bo(Department of Pharmacy,Qinghai University Medical College,Xining 810001,China) |
| Abstract: | The paper is to report the pharmacokinetics of sulfamethoxazole in healthy Han volunteers living at plain(PH) and native Han and Tibetan healthy volunteers living at high altitude(HNH and HNT).After healthy volunteers were administrated orally cotrimoxazole tablets,plasma concentration of sulfamethoxazole and metabolite N 4-acetylsulfamethoxazole was determined by RP-HPLC,and plasma concentration-time data were analyzed by DAS 2.0 software to get the related pharmacokinetic parameters.The main pharmacokinet... |
| Keywords: | sulfamethoxazole pharmacokinetics plain high altitude Han nationality Tibetan nationality |
| 本文献已被 CNKI PubMed 等数据库收录！ | |