帕金森病患者双眼竞争的研究

目的 采用双眼竞争范式，探讨帕金森病（PD）患者的双眼竞争交替速率及其可能的神经机制。方法 选取临床确诊的原发性PD患者32例（PD组）以及与其人口学资料相匹配的健康对照者32例（HC组）作为研究对象，采用双眼竞争范式进行双眼竞争交替速率的检查。结果 PD组双眼竞争交替速率[（0.24±0.07）Hz]较健康对照组[（0.35±0.11）Hz]显著减慢，且二者差异有统计学意义（t=-4.653，P=0.000）。结论 PD患者双眼竞争交替速率较健康对照组显著减慢，推测因其额叶﹣基底节的神经通路损伤从而削弱了知觉的交替变化而影响了双眼竞争交替速率。

A study of binocular rivalry in patients with Parkinson's disease

Objective To investigate the binocular rivalry alternation rate and its possible neural mechanism in patients with Parkinson's disease (PD) using binocular rivalry paradigm.Methods A total of 32 idiopathic PD patients with a confirmed diagnosis were enrolled as PD group, and 32 healthy controls matched for demographic data were enrolled as HC group. To assess the binocular rivalry alternating rate using binocular rivalry test.Results The PD group had a significantly lower binocular rivalry alternation rate than the HC group (0.24±0.07 Hz vs 0.35±0.11 Hz, t=-4.653, P=0.000).Conclusions PD patients have a significantly lower binocular rivalry alternation rate than healthy controls, which may be associated with weakened perceptual alteration caused by frontal lobe-basal ganglia nerve pathway injury.