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Efficacy and safety of amoxicillin and clavulanate for oral suspension combined with rabeprazole for helicobacter pylori eradication in children.

??Abstract??Objecive??To compare the efficacy and safety of 10-day sequential treatment??including rabeprazole?? amoxicillin and clavulanate for oral suspension??clarithromycin?? and 7-day traditional trigeminy therapy ??including omeprazole?? amoxicillin and clarithromycin?? for the eradication of helicobacter pylori??HP??in children. Methods??From Oct.2006 to Aug.2009??123 children with gastropathy with Hp infection??in Luoyang Locomotive Hospital of Henan??were divided into two groups.The control group ??41?? was treated with traditional trigeminy therapy for 7 days??while the treatment group??82??was treated with 10-day sequential treatment.Cure rates of the ulcer healing and Hp eradication were assessed after treatment course of 7-10 days??while the symptom scores and the side effect were evaluated and investigated after the treatment. Results The healing rate of ulcer in control group was 40%??2/5????which was 55.5%??5/9?? in the treatment group??the difference being statistically significant??P??0.05??. The Hp eradication rate was 92.68%??76/82??and 70.73%??29/41??in treatment group and control group?? respectively .There was significant statistical difference??P??0.05??. The total symptom score of treatment group before treatment was??56.89±4.32???? and after treatment it was ??14.96±2.13????while that of control group before treatment was ??58.75 ± 5.12?? and ??21.42 ± 3.78?? after treatment??P??0.05 or P??0.01????the change of treatment group being more significant??P??0.01??. The side effect rate of treatment group was lower than that of control group ??6.1% VS 17.1%??respectirely??P??0.05??. Conclusion??The 10-day sequential treatment??including rabeprazole??amoxicillin and clavulanate for oral suspension and clarithromycin??is much more efficient with lower side effect than 7-day traditional trigeminy therapy for Hp eradication in children with gastropathy with Hp infection.